Polyethylene glycol (PEG) reagent

Details Polyethylene glycol (PEG) reagent Polyethylene glycol (PEG) reagent

1985-10-29

1987-03-17

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568623, C07C 4136

Patent

active

046509097

ABSTRACT:
A process for production of improved polyethylene glycol (PEG) is disclosed. This process overcomes the toxicity that results from using the known (and impure) PEG-fusion reagent by incorporation of a purification method that removes the toxic elements always present in PEG preparations stored above 0.degree. C. in the presence of oxygen.

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Merck Index, ninth ed., 1976, Merck & Co., Rahway, N.J., p. 984.
Kadish et al, Hybridoma, vol. 2, No. 1, 1983, pp. 87-89.
Bratanov et al, Dokl. Bolg. Akad. Nauk., 36(3) pp. 385-387, 1983.
Schaffner, W., Proc. Natl. Acad. Sci., vol. 77, p. 2163 (1980).
Rassoulzadegan et al, Nature, vol. 295, p. 257 (1982).
Sandri-Goldin, et al, Molecular and Cellular Biology, vol. 1, p. 743 (1981).

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