Polyethylene glycol-modified semiconductor nanoparticles,...

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Reexamination Certificate

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C428S407000, C252S30160S, C252S30140S, C252S30140R

Reexamination Certificate

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07041371

ABSTRACT:
This invention provides PEG-modified semiconductor nanoparticles of which fluorescence intensity is effectively inhibited from lowering, which are capable of forming a stable dispersion in water, and which are capable of bonding easily with biomolecules having specific recognition, as well as methods for conveniently preparing such nanoparticles, and a material for biological diagnosis. The water-soluble PEG-modified semiconductor nanoparticles of the present invention includes a structure having PEG of a number average molecular weight of 300 to 20000 having a thiol group at one end, bonded via cadmium to II–VI semiconductor nanocrystals of a core-shell structure having a ZnX (wherein X stands for O, S, Se, or Te) shell.

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Andrey L. Rogach, et al., “Synthesis and Characterization of a Size Series of Extremely Small Thiol-Stabilized CdSe Nanocrystals”, J. Phys. Chem. B, 1999, 103, 3065-3069.
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