Polyethylene (glycol) derivatives with proximal reactive groups

Details Polyethylene (glycol) derivatives with proximal reactive groups Polyethylene (glycol) derivatives with proximal reactive groups

2007-05-29

2007-05-29

Nutter, Nathan M. (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

C525S056000, C568S303000, C568S305000, C568S377000, C568S420000, C568S579000, C568S583000, C568S589000, C568S606000, C568S613000, C568S618000, C568S700000, C568S704000

Reexamination Certificate

active

11314912

ABSTRACT:
An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.

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