Polyethylene glycol derivatives, their modified peptides, method

Details Polyethylene glycol derivatives, their modified peptides, method Polyethylene glycol derivatives, their modified peptides, method

1991-08-15

1993-02-02

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

435188, 514 2, 514 12, 530345, 530399, 530406, 530410, 562465, 562473, A61K 3702, A61K 3748, C07C 6304, C07C 6521

Patent

active

051836602

ABSTRACT:
Polyethylene glycol derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a lower alkyl, m and n are the same or different and each represents a positive integer and p is 0 or a positive integer, peptides modified by the polyethylene glycol derivatives, methods for producing them and use of the modified peptides. The peptides modified by the polyethylene glycol derivatives (I) of the invention, as compared with the corresponding non-modified peptides, show decreased antigenicity, are considerably delayed in biological clearance, and exhibit their physiological activities effectively over a long period, rendering them very effective as pharmaceuticals as well as drugs for animals.

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