Polyethylene glycol derivatives for solid-phase applications

Details Polyethylene glycol derivatives for solid-phase applications Polyethylene glycol derivatives for solid-phase applications

1991-09-16

1993-08-10

Schofer, Joseph L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

525374, 525379, 525382, 525386, 530334, 530337, C08G 6926

Patent

active

052350282

ABSTRACT:
The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.

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Kimura et al., J. Org. Chem., 48:385-386 (1983).
Zalipsky et al., In Peptides: Structure and Funciton, Deber et al., (eds.), Proc. 9th Amer. Pep. Symp., pp. 257-260, Pierce Chem. Co., Rockford, Ill. (1985).
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Pillai et al., Chem. Abstract vol. 114 No. 25 (Jun. 24, 1991).
Zalipsky et al., J. Bioactive & Compat. Polymers 5:227-231 (1990).

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