Polyethylene glycol derivatives for solid-phase applications

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

525374, 525379, 525382, 525385, 525386, 528335, 530334, 530337, C08F 832, C08G 6926

Patent

active

055456987

ABSTRACT:
The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.

REFERENCES:
patent: 4115361 (1978-09-01), Schulze et al.
patent: 4229567 (1980-10-01), Sharkey
patent: 4282346 (1981-08-01), Sharkey
patent: 4581040 (1986-04-01), Sung et al.
patent: 4740582 (1988-04-01), Coquard et al.
patent: 4789721 (1988-12-01), Waddill et al.
patent: 4810261 (1989-03-01), Sung et al.
patent: 4865622 (1989-09-01), Sung
patent: 4929716 (1990-05-01), Tyrell et al.
patent: 4946933 (1990-08-01), Speranza et al.
Hellerman et al., Makromol. Chem., 184:2603-2617 (1983).
G. Odian, "Principles of Polymerization", 3d, 731-736 (1991) Wiley (New York).
M. Tomoi et al., "Synthesis and Phase-Transfer Catalytic Activity of Polymer-Supported Poly(ethylene Glycol)s,", Reactive Polymers, 10:27-36 (1989).
Pillai et al., "Synthesis of Thioredoxin Partial Sequences on a Polyethylenglycol-Grafted Polystyrene Support with a Photolytically Detachable 2-Nitrobenzyl Anchoring Group, " Chem. Abstract vol. 114:247733r (June 24, 1991).
S, Zalipsky et al., "Facile Synthesis of .alpha.-Hydroxy-w-Carboxymethylpolethlene Oxide, " J. Bioactive & Compat. Polymers, 5:227-231 (1990).
Barany and Albericio, "Mild Orthogonal Solid-Phase Peptide Synthesis. "In Peptides 1990, Giralt and Andreu (Eds.), ESCOM Science Publishers B.V., pp. 139-142 (1990).
Barany et al., "Biopolymer Syntheses on Novel Polyethylene Glycol-Polystyrene (PEG-PS) Graft Supports. "In Peptides, Smith and River (Eds.) ESCOM, Proceedings of the Twelfth American Peptides Symposium, Jun. 16-21, 1991, Cambridge, MA.
Barany et al., "Peptide Synthesis on Novel Polyethyleneglycol-Polystyrene (PEG-PS) Graft Supports, " Milligen/Biosearch Forum, Sep. 6, 1990.
Odigan, G., "Principles of Polymerization, " Third Edition, 731-736 (1991), Wiley (New York).
Haridasan, V.K., et al., "Synthesis of Substance P Partial Sequential Peptides on a Photolytically Removable 4-Aminomethyl-3-nitrobenzolaminomethyl Polystyrene Support, " Chem. Abstract vol. 114:247769g (Jun. 24, 1991).
W. M. McKenzie et al., "Polymer-supported Phase Transfer Catalysts in Solid-Liquid Reactions, " J. Chem. Soc. Chem. Commun., pp. 541-543 (1978).
S. L. Regen et al., "Solid-Phase Cosolvents. Triphase Catalytic Hydrolysis of 1-Bromoadamantane, " J. Amer. Chem. Soc., 101(1):116-120 (Jan. 3, 1979).
J. G. Heffernan et al., "Non-supported and Resin-supported Oligo (oxyethylenes) as Solid-Liquid Phase-transfer Catalysts. Effect of Chain Length and Head-group, " J. Chem. Soc. Perkin II, pp. 514-517 (1981).
H. Becker et al., "Polyethylenglycols Grafted Onto Crosslinked Polystyrenes: A new Class of Hydrophilic Polymeric Supports for Peptide Synthesis, " Makromol. Chem., Rapid Commun., 3:217-223 (1982).
E. Bayer et al., "Immobolized Polyoxyethlene, A New Support For Peptide Synthesis. " In Peptides: Structure and Function, Hruby and Rich (Eds.), Proc. 8th Am. Peptide Symp. pp. 87-90, Pierce Chem. Co., Rockford, IL (1983).
H. Hellermann et al., "Poly (etylene glycol)s Grafted Onto Crosslinked Polystyrenes, 2 .sup.a) , Multidetachably Anchored Polymer Systems for the Synthesis of Solubilized Peptides, " Makromol. Chem., 184:2603-2617 (1983).
Y. Kimura et al., "Poly(ethylene glycol) -Grafted Copolymers as Synthetic Equivalents of Benzyltriethylammonium Chloride for Triphase Catalytic Alkylation .sup.1 , " J. Org. Chem., 48:385-386 (1983).
Zalipsky et al. "Preparation and Use of an Aminoethyl Polyethylene Glycol-Crosslinked Polystyrene Graft Resin Support for Solid-Phase Peptide Synthesis .sup.1 , " In Peptides: Structure and Function, Deber et al., (Eds. ), Proc. 9th Amer. Pep. Symp., pp. 257-260 Pierce Chem. Co., Rockford, IL (1985).
Bayer and Rapp, Abstract from World Patent Index (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polyethylene glycol derivatives for solid-phase applications does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyethylene glycol derivatives for solid-phase applications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyethylene glycol derivatives for solid-phase applications will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1048519

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.