Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-07-15
2008-07-15
Andres, Janet L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
10945467
ABSTRACT:
Disclosed are compounds that are derivatives of brevetoxin, or PbTx, pharmaceutical formulations comprising the compounds, and methods of regulating mucus transport in a cell, treating mucociliary dysfunction and diseases related to decreased mucus transport, wherein the compounds are of the Formula (I), and Formula (III):wherein R, R1, R2, R3, A, n, and Y are as defined herein for each compound.
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Keck et al., Tetrahedron Lett., 1987, 28:139-142.
Kirkpatrick, Harmful Algae, 2004, 3:99-115.
Lauredo, et al., Am. J. Physiol Lung Cell Mol Physiol, 2004, 286:L734-L740.
LePage et al., Brain Research 2003, 959(1):120-127.
Liu et al., Tetrahedron Lett., 2000, 56(30):5391-5404.
Mall et al., Nature Medicine 2004, 10(5):487-493.
Mende et al., Tetrahedron Lett. 1990, 31(37):5307-5310.
Nicolaou et al., J. Am. Chem. Soc. 1995, 117:1171.
Poli et al., Journal of AOAC International 1995, 78(2):538-42.
Poli et al., Molecular Pharmacology 1986, 30:129-135.
Purkerson-Parker et al., 1999, 20(6):909-920.
Purkerson-Parker et al., Chemistry & Biology 2000, 7(6):385-393.
Rein et al., Journal of Organic Chemistry 1994, 59(8):2107-13.
Rein et al., J. Org. Chem. 1994, 59:2101-2106.
Trainer et al., Molec. Pharm. 1991, 40(6):988-994.
Walsh, Comparative Biochemistry and Physiology Part B, 2003, 136:173-182.
Washburn, Toxicon, 1994, 32(7):799-805.
Wegner, Current Pharmaceutical Design, 2001, 7(3):199-212.
Whitney, Natural Toxins 1996, 4:261-270.
Abraham William M.
Baden Daniel G.
Bourdelais Andrea J.
Andres Janet L.
McDonnell & Boehnen Hulbert & Berghoff
Robinson Binta M
University of North Carolina at Wilmington
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