Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof
Patent
1988-11-09
1993-11-30
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus acids or salts thereof
558155, 558163, 558165, 558184, 558186, 558189, 562 23, C07F 938, C07F 940
Patent
active
052667227
ABSTRACT:
Polyether bis-phosphonic acid compounds are disclosed which have the formula (HO).sub.2 OP--R--(OR').sub.n --OR--PO(OH).sub.2 where R is selected from the group consisting of methylene and ethylene, R' is selected from the group consisting of ethylene and ethylene substituted with one or more methyl groups, and n is an integer from 1 to 4, water soluble salts thereof, and esters thereof with alkyl groups having from 1 to 6 carbon atoms. Also disclosed is a novel preparation of certain of these compounds by reacting certain hydroxyalkylphosphonic acid dialkyl ester compounds with certain 2-benzyloxyalkyl organic sulfonates; reacting the intermediate formed therefrom with hydrogen or a hydrogen source; reacting the intermediate formed therefrom with a hydrogen ion acceptor and certain sulfonyl chlorides; and reacting the intermediate formed therefrom with certain hydroxyalkyl-phosphonic acid dialkyl ester compounds to form a polyether bis-phosphonic acid compound which may be hydrolyzed to form the polyether bis-phosphonic acid. Useful intermediates are disclosed which have the formulas ##STR1## HOR'--OR--PO(OR").sub.2, HOR'--OR--PO(OH).sub.2, and X--O.sub.2 S--OR'--OR--PO(OR").sub.2, wherein the above-indicated benzene rings of said formulas are optionally substituted with selected groups, wherein R and R' are as defined above, wherein R" is an alkyl group having from 1 to 6 carbon atoms, and wherein X is selected from ##STR2## and alkyl groups having from about 1 to 6 carbon atoms.
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Carter Charles G.
Kumar Ranjit
Barr James P.
Bernhardt Emily
W. R. Grace & Co.,-Conn.
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