Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1998-08-20
2000-04-11
Acquah, Samuel A.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
528361, 424 55, 424 7808, 424 7838, 424486, 424497, A61K 31765, C08G 6306
Patent
active
06048523&
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a polyester cyclic compound, a complex of the cyclic compound and a compound containing a OH group or groups, and a bonded body of an ester compound and the cyclic compound or the complex, which demonstrate various pharmacological effects, such as carcinostatic effect and immunological regulation, to a living body.
BACKGROUND ART
Recently, relationship between enteric bacteria and carcinogenesis has been researched progressively. Particularly, it is said that change in intestinal bacterial flora plays a major role in the formation of carcinogens and substances for promoting carcinogenesis and their activation or suppression.
Especially, utility of lactic acid bacteria attracts attention and it is said that immune response of a host may be improved by supplying lactic acid bacteria or products of cultivation thereof, and that lactic acid bacteria may suppress proliferation of intestinal bacteria relating to production of carcinogens and carcinogenesis-promoting substances to suppress occurrence of tumors.
However, which substance among products of lactic acid bacteria provides such effects has not known yet.
Besides, Lactic acid is well known as a main substance produced by lactic acid bacteria. Lactic acid is an usual component in animal's bodies and is produced in muscles. Most of produced lactic acid is utilized as a substrate for TCA cycle or gluconeogenesis in the liver or kidney.
DISCLOSURE OF INVENTION
The inventors considered such circumstance and made intensive research on the subject, and finally found that specific polyester cyclic compound synthesized from a hydroxy acid such as lactic acid demonstrated various pharmacological effects, such as carcinostatic effect and immunological regulation, specifically to a living body.
The inventors further made research for improving the effects of the polyester cyclic compound and found that a complex formed by mixing and heating the polyester cyclic compound and a compound containing a OH group or groups (referred as "OH group-containing compound" below) demonstrated various pharmacological effects more specifically to a living body.
Moreover, the inventors found that the polyester cyclic compound or the complex bonded with an ester compound, such as a phosphoric ester, sulfuric ester or carbonic ester with a low or high molecular weight, to form a bonded body and be further stabilized. The bonded body also demonstrated various pharmacological effects.
The invention was established based on these discoveries. Namely, it is an object of the invention to provide a novel polyester cyclic compound, its complex and a bonded body of the polyester cyclic compound which demonstrate various pharmacological effects such as carcinostatic effect and immunological regulation.
To give a solution to the above problems, the invention provides a polyester cyclic compound represented by the following formula (1) ##STR1## (in the formula (1), each "R" is independently hydrogen atom, an alkyl group having 1-5 carbon atoms, or an alkyl group having 1-5 carbon atoms wherein one or more hydrogen atom is replaced by a fluorine atom, and "n" is an integer of 2 to 9), or the following formula (2). ##STR2## ("n" is same as above).
The invention further provides a complex of at least one compound containing a OH group or groups therein and at least one polyester cyclic compound selected from a group consisting of a compound of the following formula (1), a compound of the following formula (3) and a compound of the following formula (4). ##STR3## (in the formulas, "R" and "n" are same as above).
The invention further provides a bonded body obtained by bonding of at least one ester compound and at least one polyester cyclic compound selected from a group consisting of a compound of the following formula (1), a compound of the following formula (3) and a compound of the following formula (4) ##STR4## (in the formulas, "R" and "n" are same as above), or by bonding of at least one ester compound and at least one complex of said pol
REFERENCES:
Chemical Abstracts, vol. 89, No. 13, 1978, Columbus, Ohio, US; abstract No. 108036t, Dale et al, "Cyclic Oligoesters of Glycolic Acid", p. 790.
ACTA Chem. Scand. Ser. B, vol. B32, No. 4, 1978, Sweden, p. 306-307.
Isa Etsuko
Sakairi Masaki
Sone Hisao
Yoshizawa Noriko
Acquah Samuel A.
Global Art Co. Ltd.
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