Polyene polyketides and methods of production

Details Polyene polyketides and methods of production Polyene polyketides and methods of production

2007-11-27

2007-11-27

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S075000, C435S821000, C536S004100, C544S224000

Reexamination Certificate

active

10937379

ABSTRACT:
Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation ofAmycolatopsis orientalisATCC™ 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.

REFERENCES:
patent: 3854480 (1974-12-01), Zaffaroni
patent: 4452775 (1984-06-01), Kent
patent: 4920215 (1990-04-01), Holdom et al.
patent: 5039660 (1991-08-01), Leonard et al.
patent: 5286649 (1994-02-01), Konishi et al.
patent: 5523288 (1996-06-01), Cohen et al.
patent: 5783561 (1998-07-01), Horwitz et al.
patent: 5917084 (1999-06-01), Jiang
patent: 6140306 (2000-10-01), Lambert et al.
patent: 6953679 (2005-10-01), Salvati et al.
patent: 2352451 (2003-04-01), None
patent: WO 01/34816 (2001-05-01), None
patent: 03/062458 (2003-07-01), None
Igarashi Y. et al. The Journal of Antibiotics (2003) vol. 56, No. 8, pp. 705-708 “Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal—Activity fromStreptomyces hygroscopicusTP-A0623”.
Zazoupoulos E. et al., Database GenBank AF546140 “Amycolatopsis prientalis UnbL, UnbV and UnbU genes, complete cds; Amycolatopsis orientalis Pkse and TebC gemnes, complete cds.”
Hutchinson R. et al., Current Opinion in investigational Drugs, Pharmapress US, vol. 2, No. 12, pp. 1681-1690 “Combinatorial Biosyntesis in microorganisms as a route to new antimicrobial, antitumor and neuroregenarative drugs.”
Shah, J. Antibiotics, (2000) vol. 53, No. 5, pp. 502-508 “Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin”.
Rangaswamy V. et al., Proc. Natl. Acad. Sci. (1998) vol. 95, pp. 15469-15474 “Biosynthesis of the Pseudomonas polyketide coronafacic acid requires monofunctional and multifunctional polyketide synthase proteins”.
Kakavas S. et al., J. Bacteriol. (1997) vol. 179, No. 23, pp. 7515-7522 “Identification and characterization of the Niddamycin polyketide synthase genes fromStreptomycetes caelestis”.
Brautaset T. et al., Chem. Biol., (2000) vol. 7, No. 6, pp. 395-403 “Biosynthesis of the polyene antifungal antibiotic nystatin inStreptomyces nourselATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway”.
Fisher M. et al., Structure, (2000) vol. 8, No. 4, pp. 339-347 “The X-ray structure ofBrassica napusbeta-keto acyl carrier protein reductase and its implications for substrate bindingand catalysis”.
Berge SM et al., Journal of Pharmaceutical Sciences (1977), vol. 66, No. 1, pp. 1-19 “Pharmaceutical salts”.
Goodfellow Bergey's Manual of Systematic Bacteriology, vol. 4, Williams and Wilkins, Baltimore, (1989) vol. 4, pp. 2322-2339 “Supragenic classification of actinomycetes”.
Embley and Stakebrandt, Annu. Rev. Microbiol., (1994) vol. 48, pp. 257-289 “The molecular phylogeny and systematics of the actinomycetes”.
Gluzman Y., Cell. (1981) vol. 23, No. 1 pp. 175-182 “SV40-transformed simian cells support the replication of early SV40 mutants”.
Leung D.W. et al., Technique (1989) vol. 1, pp. 11-15 “A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction”.
Caldwell R.C. and Joyce G.F., PCR Methods Applic. (1992) vol. 2, pp. 28-33 “Randomization of genes by PCR mutagenesis”.
Reidhaar-Olson J.F. et al., Science (1988) vol. 241 (4861), pp. 53-57 “Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences”.
McDaniel R. et al., Proc Natl Acad Sci USA (1999)vol. 96, pp. 1846-1851 “Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unatural” natural products”.
Zazopoulos E. et al., Nature Biotechnol. (2003) vol. 21, pp. 187-190 “A genomic-guided approach for discovering and expressing cryptic metabolic pathways”.
Stryer Biochemistry 3rd edition (1998) W.H. Freeman and Co., New York, pp. 752-754.
Altschul S. et al., J. Mol. Biol. (1990) vol. 215, pp. 403-410 “Basic local alignment search tool”.
Hopwood D., Chem Rev., (1997) vol. 97, No. 7, pp. 2465-2497 “Genetic contributions to understanding polyketide synthases”.
Zahn J. et al., Applied and Environmental Microbiology (2001) vol. 67, No. 1, pp. 377-386 “Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved condtions for expression of secondary metabolites from actinomycetes”.
Kanzaki H. et al., Biosci Biotechnol Biochem (1998) vol. 62, pp. 438-442 “Novel bioactive oxazolomycin isomers produced byStreptomyces albusJA 3453”.
Blanco et al., Mol. Gen. Genet. (2000) vol. 262, No. 6, pp. 991-1000 “Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin byStreptomyces argillaceaus”.
Chen et al., Gene (2001) vol. 263, No. 1-2, pp. 255-264 “TheStreptomyces venezuelaepikA V gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide”.
Oh SH and Chater J., Journal of Bacteriology (1997)vol. 179, No. 1, pp. 122-127 “Denaturation of circular or linear DNA facilitates targeted integrative transformation ofStreptomycetes coelicolorA3(2): possible relevance to other organisms”.
Hussain and Ward, Appl. Environ. Microbiol. (2003) vol. 69, No. 1, pp. 373-382 “Enhanced heterologous expression of twoStreptomyces griseoluscytochrome P450's andStreptomyces coelicolorferredoxin reductase as potentially efficient hydroxylation catalysts”.
Bartzatt et al., Biotechnol. Appl. Biochem (2002) vol. 36, pp. 89-93 “Amalysis of an ampicillin propyl ester prodrug which inhibits the growth ofEscherichia coli”.
Dhingra et al., J. Ind. Microbiol. Biotechnol. (2003) vol. 30, pp. 195-204 “Development of cloning vectors and transformation methods for amycolatopsys”.
Sakuda S. et al., Tetrahedron Letters (1995) vol. 36 No. 16, pp. 2777-2780 “Linearmycin A, a novel linear polyene antibiotic”.
Sakuda S. et al., J. Chem Soc., Perkin Trans. (1996) vol. 1 pp. 2315-2319 “Novel linear polyene antibiotics: linearmycins”.
Goodfellow, Bergey's Manual of Systematic Bacteriology (1989), vol. 4, Williams and Wilkins, Baltimore, pp. 2322-2339.
Argoudelis et al., J. of Antibiotics, vol. XL, No. 6, Jun. 1987, pp. 750-760 “Arginomycin: production, isolation, characterization and structure”.
Vaara M. Microbiological review (1992) vol. 56, No. 3, pp. 395-411 “Agents that increase the permeability of the outer membrane”.
Tsubery H. et al., Med. Chem. (2000) vol. 43 (16) pp. 3085-3092 “Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria”.
Hutchinson, C. R., et al. Combinatorial biosynthesis in microorganisms as a route to new antimicrobial, antitumor and neuroregenerative drugs, Current Opinion in Investigational Drugs, Dec. 2001, pp. 1681-1690, vol. 2, No. 12, PharmaPress Ltd.
Zazopoulos, E.,et al. A genomics-guided approach for discovering and expressing cryptic metabolic pathways, XP-002356578; GenBank Accession No. AF546140.
Igarashi, Yasuhiro,et al. “Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal Activity fromStreptomyces hygroscopicusTP-A0623 II, Physico-chemical Properties and Structure Determination,” The Journal of Antibiotics, Aug. 2003, pp. 705-708, vol. 56 No. 8, Japan Research Association, Tokyo, Japan.

Affiliated with

Also associated with

Rating

Polyene polyketides and methods of production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyene polyketides and methods of production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyene polyketides and methods of production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3877595