Polyene microlide pre-liposomal powders

Details Polyene microlide pre-liposomal powders Polyene microlide pre-liposomal powders

1987-10-16

1990-08-21

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

514 31, 514 37, 424450, 424502, A61K 9133, A61K 9127, B01J 1302

Patent

active

049504320

ABSTRACT:
The present invention involves a process for producing fine powder suitable for the preparation of antifungal polyene microlide-containing liposomes upon suspension in an aqueous solution. This process comprises the following steps. Quantities of polyene macrolide and phospholipids are dissolved respectively in a first solvent and a second solvent to form a first solution and a second solution. The first solution and the second solution are mixed in a desired ratio to form a mixture. The first solvent and the second solvent are then removed from the mixture, for example by evaporation, to form a residue. The residue is then dissolved in a third solvent comprising tertiary butanol and methylene chloride to form a third solution. The third solvent is then removed from the third solution to form a remnant. The remnant is then dissolved in a solvent consisting essentially of tertiary butanol to form a fourth solution. The fourth solution is then filtered through a filter having orifices of between about 0.05 and 0.5 micrometers in diameter to produce a filtrate. The filtrate is lyophilized to remove the tertiary butanol and a fine powder remains. This fine powder may be used to form polyene macrolide-containing liposomes by simple incubation or suspension in an aqueous solution.

REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4186183 (1980-01-01), Steck et al.
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4241046 (1980-12-01), Papahadjopoulos et al.
patent: 4247411 (1981-01-01), Vanlerberghe et al.
patent: 4308166 (1981-12-01), Marchetti et al.
patent: 4311712 (1982-01-01), Evans et al.
patent: 4370349 (1983-01-01), Evans et al.
patent: 4411894 (1983-10-01), Schrank et al.
patent: 4427649 (1984-01-01), Dingle et al.
patent: 4460577 (1984-07-01), Moro et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4529561 (1985-07-01), Hunt et al.
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4622188 (1986-11-01), Adamich et al.
patent: 4663167 (1987-05-01), Lopez-Berestein et al.
patent: 4687762 (1987-08-01), Fukushima et al.
patent: 4731210 (1988-03-01), Weder et al.
patent: 4737323 (1988-04-01), Martin et al.
patent: 4744989 (1988-05-01), Payne et al.
patent: 4762720 (1988-08-01), Jizomoto
patent: 4766046 (1988-08-01), Abra et al.
patent: 4812312 (1989-03-01), Lopez-Berestein
patent: 4830858 (1989-05-01), Payne et al.
patent: 4863739 (1989-09-01), Perez-Soler
Szoka et al., Ann. Rev. Biophys. BioEng., (1980), 9:467-508.
Ganapathi et al., Biochemical Pharmacology, 33:698-700, (1984).
Olsen et al., Eur. J. Cancer Clin. Oncol., 18:167-176, (1982).
International Search Report, Mar. 16, 1989.
Lopez-Berestein et al., `Treatment and Prophylaxis . . . with Liposome-Encapsulated Amphotericin B`, J. Infect. Dis., vol. 147, No. 5, (1983), pp. 939-945.

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