Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-06-04
2000-06-06
Myers, Carla J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435455, 435471, 435325, 4352523, 4353201, 536 235, 536 2431, 536 2433, 530350, 514 44, 514 2, 514 21, C07H 2104, C07K 14435, C12N 1563, C12P 2102
Patent
active
060717173
ABSTRACT:
The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1 protein or fragments thereof. In another aspect, the invention involves isolated oligonucleotides that hybridize only to the authentic expressed PKD1 gene, and not to PKD1 homologues. In yet another aspect, the invention involves isolated mutant PKD1 genes, and their cDNA cognates. Further provided are isolated oligonucleotides that discriminate between normal and mutant versions of the PKD1 gene. Methods and compositions for treating APKD or disease conditions having the characteristics of APKD are also provided.
REFERENCES:
Turco et al, Nephrology Dialysis and Transplantation (1996) 11:10-13.
Van Adelsberg et al, Nature Genetics (Apr. 1995) 1 (4): 359-364.
The EPKDC, Cell (Jun. 1994) 77:881-894.
Hughes et al, Nature Genetics (Jun. 1995) 10: 151-159.
The IPKDC, Cell (Apr. 1995) 81: 289-298.
Sambrook et al, Molecular Cloning: A Laboratory Manual, 1989 Cold Spring Harbor Laboratory Press, NY p. 16.3-16.31.
Orkin et al, 1995, Report and Recommendations to the Panel to Assess the NIH Investment in Research on Gene Therapy.
Burn et al Human Molecular Genetics (1995)4(4):575-582.
Burn Timothy
Connors Timothy
Dackowski William
Germino Gregory
Klinger Katherine
Genzyme Corporation
Johns Hopkins University
Myers Carla J.
LandOfFree
Polycystic kidney disease gene and protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polycystic kidney disease gene and protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polycystic kidney disease gene and protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2212122