Polycyclic systems, and derivatives thereof, as neurotransmitter

Details Polycyclic systems, and derivatives thereof, as neurotransmitter Polycyclic systems, and derivatives thereof, as neurotransmitter

1996-06-17

1999-11-23

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546187, A61K 3144, C07D40906

Patent

active

059901322

ABSTRACT:
Compounds of Formula (I) have been shown to enhance the release of the neurotransmitter acetylcholine, and thus may be useful in the treatment of diseases of man where subnormal levels of this neurochemical are found, such as in Alzheimer's disease, and other conditions involving learning and cognition. This invention describes compounds, pharmaceutical compositions and methods of treatment comprising compounds of Formula (I): ##STR1##

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patent: 5359070 (1994-10-01), Cherney et al.
patent: 5532249 (1996-07-01), Wilkerson et al.
DeNoble, et al., Pharmacol. Biochem. Behavior, (199) 36:957.
Cook, et al., Drug Development Research (1990) 19: 301.
Nickolson, et al., Drug Development Research (1990) 19: 285.
Earl, et al., Bioorganic and Medicinal Chemistry Letters, vol. 2, No. 8, 1996, pp. 851-854.

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