Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-29
2005-03-29
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S260100, C514S266300, C544S253000, C544S278000, C544S285000
Reexamination Certificate
active
06872727
ABSTRACT:
Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.
REFERENCES:
patent: 293816 (1991-09-01), None
patent: 293824 (1991-09-01), None
patent: 0454060 (1991-10-01), None
Leistner et al., Chemical Abstracts, vol. 116:83689, 1992.*
Kluge et al., Chemical Abstracts, vol. 116:53664, 1992.
Herrmann Konrad
Leistner Siegfried
Wippich Petra
Privates Institut fur Biomedizinische Forschung und Beratung
Raymond Richard L.
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