Polycyclic heterocyclic compounds, a process for their preparati

Details Polycyclic heterocyclic compounds, a process for their preparati Polycyclic heterocyclic compounds, a process for their preparati

1990-04-24

1991-02-05

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 187, 544137, 544368, 546198, 548224, 5142328, 514253, 514321, 514375, 514863, 514880, 514912, A61K 3142, A61K 31535, C07D41310

Patent

active

RE0335339

ABSTRACT:
A polycyclic heterocyclic compound has the formula ##STR1## wherein n is 1 or 2, R.sub.1 represents (i) lower alkyl, (ii)--CH.sub.2 OH or (iii) ##STR2## R.sub.2 represents (a) hydrogen, (b) ##STR3## or (c)--OR.sub.3, R.sub.3 represents hydrogen, C.sub.1 -C.sub.20 alkyl mono or polyhydroxyalkyl, aryl or aralkyl optionally substituted, the residue of a sugar or wherein p is 1, 2, or 3, and r' and r" represent hydrogen, lower alkyl, mono or polyhydroxalkyl, aryl optionally substituted, amino acid residue, aminated sugar residue, or together form a heterocycle, X represents oxygen, sulfur, SO, SO.sub.2 or --NR.sub.4, Y represents CR.sub.4 or a nitrogen atom and R.sub.4 represents hydrogen or lower alkyl. This polycyclic heterocyclic compound can be used in human and veterinary medicine and especially in the topical or systemic treatment of determatologic diseases.

REFERENCES:
patent: 4659360 (1987-04-01), Baum et al.
patent: 4740519 (1988-04-01), Shroot et al.

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