Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1990-12-17
1992-03-31
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 76, 4352521, 435105, 536 186, 536 168, 514 27, C12N 120, C12P 1902, C12P 1962, C07H 1700
Patent
active
051007851
ABSTRACT:
A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.
REFERENCES:
patent: 4278663 (1981-07-01), Liu et al.
patent: 4565862 (1986-01-01), Foley et al.
Bergey's Manual of Systematic Bacteriology, vol. 2, p. 1459.
Cullen Walter P.
Maeda Hiroshi
Ruddock John C.
Tone Junsuke
Brokke Mervin E.
Brown Johnnie R.
Lumb J. Trevor
Pfizer Inc.
Richardson Peter C.
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