Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1979-12-06
1983-07-26
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260464, C07C12148, A61K 31275
Patent
active
043954235
ABSTRACT:
(18.beta. and 18.alpha.)-2.alpha.-Cyano-3,11-dioxo-olean-12-en-29-oic acids and lower-alkyl esters thereof, useful as ulcer preventing and ulcer healing agents, are prepared from 18.beta.- or 18.alpha.-glycyrrhetinic acid, the final step being alkaline cleavage of 18.beta.- or 18.alpha.-11-oxo-olean-2,12-dieno[2,3-d]isoxazol-29-oic acid or an ester thereof.
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patent: 3070623 (1967-12-01), Gottfried et al.
patent: 3296255 (1967-01-01), Clinton et al.
Tolstikov et al., Izvestia Akademi Nauk Kazakhskoi SSR, Seriya Khimicheskaya, 17, 71-78, (1967).
Yasue et al., Yakugaku Zasshi, 93, 296-299, (1973).
The Merck Index, 8th Ed., 1968, p. 502.
Tolstikov et al., Jour. of Gen. Chem., U.S.S.R., 34, (1964), p. 3181.
Tolstikov et al., Zhurnal Obshchei Khimii, 34, (1964), pp. 3133-3134.
C. A., 74, (1971), 54022e, Kim et al.
Kim et al., Izv. Akad. Nauk. Kaz. SSR, Ser. Khim., (1970), 20(6), pp. 49-54.
C. A., 94, (1981), 103626d, Neumann.
Brust Joseph Paul
Johnson Thomas L.
Sterling Drug Inc.
Wyatt B. Woodrow
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