Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-11-06
1993-11-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540545, C07D49822, A61K 3155
Patent
active
052644316
ABSTRACT:
Staurosporin derivatives of the formula I are described, ##STR1## in which R.sub.1 is hydrogen, hydroxyl, lower alkoxy or oxo and R.sub.2 is a radical of the formula II ##STR2## in which the configuration of the sugar moiety is derived from D-glucose, D-galactose or D-mannose, and R.sub.3 -R.sub.7 are as defined below.
These compounds have a pronounced and selective inhibitory action on the enzyme proteinkinase C and have, inter alia, an antitumor action.
REFERENCES:
patent: 4256735 (1981-03-01), Durette et al.
patent: 4315913 (1982-02-01), Durette
patent: 5093330 (1992-03-01), Caravatti et al.
Takahashi, et al. "Potent Selective Inhibition of 7-0-Methyl UCN-01 Against Protein Kinase C" The Journal of Pharmacology and Experimental Therapeutics, vol. 255, No. 3 pp. 1218-1221 (1990).
Traxler Peter
Wacker Oskar
Ciba-Geigy Corp.
Datlow Philip F.
Fishman Irving M.
Ikeler Barbara J.
Kaiser Karen G.
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