(Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene bi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548494, C07D20918, A61K 31405

Patent

active

051909685

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

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Sheinkman et al., Chem. Ab., vol. 67, 54017 (1967).
Biniecki et al., Chem. Ab., vol. 98, 197936 (1983).
Pakula et al., Chem. Ab., vol. 105, 190835 (1986).

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