(Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene bi

Details (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene bi (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene bi

1991-09-30

1993-03-02

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548494, C07D20918, A61K 31405

Patent

active

051909685

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

REFERENCES:
patent: 4629733 (1986-12-01), Muiller et al.
patent: 5081145 (1992-01-01), Gundon
patent: 5095031 (1992-03-01), Brooks et al.
Sheinkman et al., Chem. Ab., vol. 67, 54017 (1967).
Biniecki et al., Chem. Ab., vol. 98, 197936 (1983).
Pakula et al., Chem. Ab., vol. 105, 190835 (1986).

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