Polycyclic amine compounds and their enantiomers, their method o

Details Polycyclic amine compounds and their enantiomers, their method o Polycyclic amine compounds and their enantiomers, their method o

1992-05-04

1994-08-23

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142355, 5142358, 514252, 514255, 514256, 514318, 514326, 514327, 514330, 514331, 540524, 540597, 540598, 544121, 544122, 544129, 544333, 544357, 544359, 544360, 544365, 544372, 546186, 546187, 546188, 546189, 546190, 546191, 546208, C07D40102, C07D40114, A61K 31445, A61K 3155

Patent

active

053408225

ABSTRACT:
The invention relates to polycyclic amine compounds of formula (I) ##STR1## where Y. m. Ar', n, p, Q, T, q and Z are defined herein. The invention also relates to methods of making the compounds of formula (I) and pharmaceutical compositions which contain the compounds of formula (I). The inventive compounds are useful as neurokinin receptor antagonists, and are useful for the treatment of any substance P-dependent and neurokinin-dependent pathological condition.

REFERENCES:
patent: 3562281 (1971-02-01), Werner et al.
patent: 3718743 (1973-02-01), Shen et al.
patent: 4094987 (1978-06-01), Hasspacher et al.

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