Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-01-16
1994-11-15
Michl, Paul R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 4, 514 2, A61K 4900, A61K 3700, A61K 3900, A61K 4904
Patent
active
053646134
ABSTRACT:
There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g, DOTA residues, conjugated to a polyamine backbone molecule, e.g, polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.
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Quay Steven C.
Rocklage Scott M.
Sieving Paul F.
Watson Alan D.
Michl Paul R.
Yoon Tae H.
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