Polychelants containg amide bonds

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

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424 9365, 424 9363, 534 15, 534 16, 556 50, 556 55, 556 63, 556 77, 556105, 556116, 556134, 556148, 514492, 514502, 514836, A61B 5055

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059140950

ABSTRACT:
There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a dendritic polyamine backbone molecule, e.g. a starburst dendrimer. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.

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