Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2004-10-01
2008-10-21
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S009300, C424S009363, C424S009364, C424S009365, C534S015000, C548S304100
Reexamination Certificate
active
07438893
ABSTRACT:
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.
REFERENCES:
patent: 5980862 (1999-11-01), Meade et al.
patent: 6120768 (2000-09-01), Griffiths et al.
patent: 7141676 (2006-11-01), Wilbur et al.
Elmaleh David R.
Fischman Alan J.
Shoup Timothy
Arnold Beth E.
Foley & Hoag LLP
Hartley Michael G.
Massachusetts General Hospital
Schlientz Leah
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