Polyazamacrocyclic compounds for complexation of metal ions

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540465, 540474, A61K 4900, C07D25502

Patent

active

053426061

ABSTRACT:
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses. The compound has the formula ##STR1## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y;

REFERENCES:
patent: 3930867 (1976-01-01), Bigelow
patent: 3932451 (1976-01-01), Bigelow
patent: 3987128 (1976-10-01), Richman
patent: 3996276 (1976-12-01), Atkins
patent: 4038312 (1977-07-01), Atkins
patent: 4085106 (1978-04-01), Atkins
patent: 4130715 (1978-12-01), Atkins
patent: 4337154 (1982-06-01), Fukuchi
patent: 4352751 (1982-10-01), Wieder
patent: 4421671 (1983-12-01), Cusano
patent: 4432907 (1984-02-01), Wieder
patent: 4472509 (1986-09-01), Gansow et al.
patent: 4639365 (1987-01-01), Sherry
patent: 4647447 (1987-03-01), Gries et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4735796 (1988-04-01), Gordon
patent: 4957939 (1990-09-01), Gries et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 4983376 (1991-01-01), Sherry
Cabbiness et al., "Macrocyclic Effect on the Stability of Copper (II) Tetramine Complexes", J. Am. Chem. Soc., 91(23):6540 (1969).
Martin et al., "The Relationship between Metal-Donor Distance and Ring Size in Macrocyclic Complexes", J. Am. Chem. Soc., 96(12):4046 (1974).
Richman et al., "Nitrogen Analogs of Crown Ethers", J. Am. Chem. Soc., 96(7):2268-70 (1974).
Lettvin et al., J. Mag. Res., 28:459-61 (1977).
White et al., J. Amer. Chem. Soc., 101(17):4921 (1979).
Desreux, Inorganic Chemistry, 19:1319-24 (1980).
Sherry, "A Proposal on Basic Chemical Research", submitted to the Robert A. Walsh Foundation (1981).
Bryden et al., Chemical Abstracts, No. 97:206960z (1982).
Singh, Letter dated Apr. 13, 1983 to Sherry.
Desreux, letter dated Dec. 23, 1983 to Sherry.
Brasch et al., A. J. R., 142:625-30 (1984).
Chen et al., Fed. Euro. Biochem. Soc., 168(1):70 (1984).
Goldstein et al., Physiol. Chem. & Phys. & Med. NMR, 16:97-104 (1984).
Sherry, Letter dated Apr. 4, 1984 to Schmidt.
Weinmann et al., A. J. R., 142:619-24 (1984).
Wolf, Physiol. Chem. & Phys. & Med. NMR, 16:93-95 (1984).
Geraldes et al., Inorganic Chemistry, 24(23):3876 (1985).
Geraldes et al., Journal of Magnetic Resonance, 66:274-82 (1986).
Geraldes et al., Magnetic Resonance in Medicine, 3:242-50 (1986).
Sherry et al., Journal of Magnetic Resonance, 66:511-24 (1986).
Chavez et al., J. Org. Chem., 54(12):2990-92 (1989).
Sherry, J. Less Common Metals, 149:133-41 (1989).
Lazar et al. (1991) "N,N',N"-Tris(methoxymethyl)-1,4,7-triazacyclononane: a New Synthetic Tool for the Synthesis of Tris-N-substituted 1,4,7-Triazacyclononane Derivatives", J. Chem. Soc., Chem. Commun., Nr. 18:1252-1253, published in Great Britain.
Parker et al., "Preparation of tetraphosphinate-substituted tetraaza macrocycles for use as antitumor or imaging agents", Chem. Abstr. 114:122706c (1991) citing European Patent Application EP 382,582, Aug. 16, 1990.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polyazamacrocyclic compounds for complexation of metal ions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyazamacrocyclic compounds for complexation of metal ions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyazamacrocyclic compounds for complexation of metal ions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-28338

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.