Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1995-06-06
1997-08-12
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 169, 424 936, 534 10, 534 15, 5483411, 548518, 564253, 564268, 546256, A61K 5104, A61B 5055, C07F 500, C07D23354
Patent
active
056562543
ABSTRACT:
Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
REFERENCES:
patent: 3369121 (1968-02-01), Czaplinski et al.
patent: 3920995 (1975-11-01), Bruno et al.
patent: 4071613 (1978-01-01), Hunter, Jr.
patent: 4193979 (1980-03-01), Frank et al.
patent: 4272503 (1981-06-01), Camin et al.
patent: 4311689 (1982-01-01), Ruddock
patent: 4363793 (1982-12-01), Blau et al.
patent: 4431626 (1984-02-01), Henze
patent: 4444690 (1984-04-01), Fritzberg
patent: 4462992 (1984-07-01), Agrawal et al.
patent: 4615876 (1986-10-01), Troutner et al.
patent: 4638051 (1987-01-01), Burns et al.
patent: 4758682 (1988-07-01), Collins et al.
patent: 4789736 (1988-12-01), Canning et al.
patent: 4818813 (1989-04-01), Nowotnik et al.
patent: 4849511 (1989-07-01), Vebruggen
patent: 4871836 (1989-10-01), Francescono et al.
patent: 4880616 (1989-11-01), Azuma et al.
patent: 4895960 (1990-01-01), Deutsch
patent: 4925650 (1990-05-01), Nosco et al.
patent: 4980147 (1990-12-01), Fritzberg et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 4988496 (1991-01-01), Srinivasan et al.
patent: 5026829 (1991-06-01), Deutsch
patent: 5037631 (1991-08-01), Nosco
patent: 5071636 (1991-12-01), Yamauchi et al.
patent: 5075099 (1991-12-01), Srinivasan et al.
patent: 5089249 (1992-02-01), Fritzberg et al.
patent: 5091514 (1992-02-01), Fritzberg et al.
patent: 5096693 (1992-03-01), Azuma et al.
patent: 5101041 (1992-03-01), Troutner et al.
patent: 5104638 (1992-04-01), Nosco
patent: 5116596 (1992-05-01), Bremer et al.
patent: 5116598 (1992-05-01), Nosco
patent: 5164175 (1992-11-01), Bremer et al.
patent: 5164176 (1992-11-01), Gustavson et al.
patent: 5187264 (1993-02-01), Verbruggen
patent: 5302370 (1994-04-01), Neumeier et al.
patent: 5387692 (1995-02-01), Riley et al.
Elliott et al., "Synthesis of Potential Antiradiation Agents from 3-substituted 2-oxazolidinones derived from Phenol, Benzenethiol and related compounds", J. Med. Chem., vol. 12, No. 2, pp. 253-257 (1969).
Boschman et. al. ,"In vitro inhibition of ADP-induced patelet aggregation by O-(aminoalkyl) oxime ethers" Eur. J. Med. Chem.-Chem Therapeutica, Jul.-Aug. 1980, 15, No.4 pp. 351-356. (1980).
Chapman, J.D., "Measurement of Tumor Hypoxia by Invasive and Non-Invasive Procedures: A Review of Recent Clinical Studies", Radiother. Oncol., 20, pp. 13-19 (1991).
Martin, G.V. et al., "Enhanced Binding of the Hypoxic Cell Marker [.sup.3 H]Fluoromisonidazole in Ischemic Myocardium", J. Nucl. Med., vol. 30, No. 2, 194-201 (1989).
Hoffman, J.M. et al., "Binding of the Hypoxia Tracer [.sup.3 H]Misonidazole in Cerebral Ischemia".
Koh, W.J. et al., "Hypoxia Imaging of Tumors Using [F-18] Fluoromisonidazole", J.Nucl.Med., 30,789 (No. 252) (1989).
Biskupiak, J.E. et al., "Synthesis of an (Iodovinyl)misonidazole Derivative for Hypoxia Imaging", J. Med. Chem., 34, pp. 2165-2168 (1991).
Chapman, J.D., "The Detection and Measurment of Hypoxic Cells in Solid Tumors", Cancer, Vo. 54, No. 11, pp. 2441-2449 (1984).
Kedderis, G.L. et al, "The Metabolic Activation of Nitroheterocyclic Therapeutic Agents", Drug Metabolism Reviews, 19(1), pp. 33-62 (1988).
Adams, G.E. et al., "Hypoxia-Mediated Nitro-Heterocyclic Drugs in The Radio-and Chemotherapy of Cancer", Biochemical Pharmacology, vol. 35, No. 1, pp. 71-76 (1986).
Brown, D.M. et al., "Structure-Activity Reationships of 1-Substituted 2-Nitroimidazoles: Effect of Partition Coefficient and Side-chain Hydroxyl Groups on Radiosensitization In Vitro", Radiation Research, 90, pp. 98-108 (1982).
Adams, G.E., et al., "Structure Activity Relationships in the Development of Hypoxic Cell Radiosensitizers. I. Sensitizatoin Efficiency", Int. J. Radiat. Biol., vol. 35, No. 2, pp. 133-150 (1979).
Adams, G.E., et al., "Structure Activity Relationships in the Development of Hypoxic Cell Radiosensitizers. III. Effects of Basic Substitutents in Nitromidazole Sidechains", Int. J. Radiat. Biol., vol. 38, No. 6, pp. 613-626 (1980).
Jerabek, P.A., et al., "Synthesis and Biodistribution of .sup.18 F-Labeld Fluoronitroimidazoles: Potential In Vivo Markers of Hypoxic Tissue", Appl. Radiat. Isot. vol. 37, pp. 599-605 (1986).
Martin, G.V. et al, "Fluoromisonidazole A Metabolic Marker of Myocyte Hypoxia", Circulation Research, 67, pp. 240-244 (1990).
Shelton, M.E. et al., "In Vivo Delineation of Myocardial Hypoxia During Coronary Occulsion Using Fluorin-18 Fluoromisonindazole and Position Emission Tomography: A Potntial Approach for Idntification of Jeopardized Myocardium", J. Am. College Cardiology, vol. 16, No. 2, pp. 477-485 (Aug. 1990).
Mannan, R.H. et al., "Radioiodinated 1-(5-Iodo-5-deoxy-.beta.-D-arabionofuranosyl)-2-nitroimidazole (Iodazomycin Arabinoside: IAZA): A Novel Marker of Tissue Hypoxia", The Journal of Nuclear Medicine, vol. 32, No. 9, pp. 1764-1770 (1991).
Parker, D., "Harnessing the Kinetic Stability of Macrocyclic Complexes In Vivo," presented at the 16th Int. Symp. on Macrocyclic Chemistry, Univ. of Sheffield, UK (Sep. 1-6, 1991).
Yang Kixi, et al., "Synthesis of Metronidazole and Its Distribution in Sarcoma 180 Bearing Mice", J. of Medical Colleges of PLA; 2(3) pp. 265-269 (1987).
Volkert, W.A. et al., ".sup.99 m Tc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceuticals", Eur. J. Nucl. Med., 9, pp. 511-516 (1984).
Kung, H.F., et al., "Synthesis and Biodistribution of Neutral Lipid-Soluble Tc-99m Complexes that Cross the Blood-Brain Barrier", The Journal of Nuclear Medicine, 25, pp. 326-332 (1984).
Lever, S.Z. et al., "Design, Preparation, and Biodistribution of a Technetium-99m Triaminedithiol Complex to Assess Regional Cerebral Blood Flow", J. Nucl. Med., 26, pp. 1287-1294 (1985).
Jurisson et al., "Synthesis, Characterization, and X-ray Structural Determination of Technetium (V)-Oxo-Tetradentate Amine Oxime Complexes", Inorg. Chm., 25, pp. 543-549 (1986).
Ding et al., "Review and Prospectives of Brain Radioppharmaceuticals", Nucl. Sci. J., 29(5), pp. 341-348 (1992).
Fattorusso et al., J. Chem Soc., Daltons Trans., p. 752 (1970).
Moody et al., J. Chem. Soc. Perkin Trans. 1, (1), pp. 18-24 (1972).
Svetkin et al., Zh. Obshch Khim, 41(11), pp. 2553-2555 (1971).
Hook et al., Anti-Cancer Drug Res., 4(3), pp. 173-190 (1989).
Curtius, Hechtenberg, J. Pract. Chem., 105, 314 (1922).
Orna et al., "Correlation of Kinetic Parameters of Nitroreductase Enzymes with Redox Properties of Nitroaromatic Compounds", J. Biol. Chem., vol. 264, 21, pp. 12379-12384 (1989).
Murmann, K., "The Interaction of 2-Methyl-2-amino-3-butanone Oxime with Nickel (II) and Copper (II) Ions", J. Am. Chem. Soc., pp. 4174-4180 (1958).
Vassian et al., "Aromatization of an Aliphatic Amine Oxime Nickel (II) Complex by Molecular Oxygen", Inorg. Chemistry, vol. 6, No. 11, pp. 2043-2046 (1967).
Murmann et al., "An Unsymmetrical transDinitrocobalt (III) Complex. A Crystal Structure Determination", Inorg. Chem., vol. 12, No. 11, pp. 2625-2631 (1973).
Somin et al "Oximes of w-dimethylaminoalkanals and their derivatives."Zh Organ. Khim. vol. 1 (II), pp. 1973-1976, (1965) (Russian) [Chem Abs.] vol. 64, p. 9582(f).
Corbin, et al., "Substituted Cysteame Ligands and Their Complexes with Molybdenum(VI)", Inorg. Chem. vol. 23, pp. 3404-4312, (1984).
Bryson, et al. "Neutral Technitium(V) Complexes with Amide-Thiol-Thioether Chelating Ligands" Inor. Chem. vol. 27, pp. 2154-2161, (1988).
Panakaskie et. al., Synthetic Communications, vol. 19, pp. 339-344 (1966).
Biniakiewicz et. al. "A New, General synthetic Route to Multidenate N,S Ligands for Use in Technetium-99m Radiopharmaceuticals." J. Med. Chem., vol. 35, pp. 274-279, (1992).
Raju Natarajan
Ramalingam Kondareddiar
Bracco International B.V.
Hartley Michael G.
Hoare George P.
Hollinden Gary E.
Rhoads Donald L.
LandOfFree
Polyaza heteroatom-bearing ligands and metal complexes thereof f does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polyaza heteroatom-bearing ligands and metal complexes thereof f, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyaza heteroatom-bearing ligands and metal complexes thereof f will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-158009