Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-12-16
1996-09-17
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546174, 546216, 546194, 546198, 5462784, 5462787, 5462791, 546207, 546314, 5462701, 5462717, 546261, 546262, 548170, 540512, 540524, C07D20704, C07D40308, C07D41706, C07D21114, C07D22302
Patent
active
055569900
ABSTRACT:
This invention relates to a class of novel dicarboxy amide derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis-aryl and/or heteroaryl alkyl or cycloalkylamino dicarboxy amides. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
Cha Don D.
Choi Yong-Mi
Maguire Martin P.
Pauls Henry W.
Spada Alfred P.
Nicholson James A.
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Savitzky Martin F.
Springer David B.
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