Polyanionic polymers which enhance fusogenicity

Details Polyanionic polymers which enhance fusogenicity Polyanionic polymers which enhance fusogenicity

2006-01-17

2006-01-17

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S001210, C424S009321, C424S009510, C525S007000, C525S050000, C525S295000, C528S392000

Reexamination Certificate

active

06986902

ABSTRACT:
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.

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