Polyanionic benzylglycosides as inhibitors of smooth muscle cell

Details Polyanionic benzylglycosides as inhibitors of smooth muscle cell Polyanionic benzylglycosides as inhibitors of smooth muscle cell

1994-11-07

1996-03-12

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514460, 536 175, 536 179, 549476, 549478, A61K 3170, C07H 1500

Patent

active

054987750

ABSTRACT:
This invention relates to the use of polyanionic benzylglycosides as smooth muscle cell proliferation inhibitors and as therapeutic compositions for treating diseases and conditions which are characterized by excessive smooth muscle proliferation, such as restenosis. The compounds of this invention are those of formula I ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are, independently, H, SO.sub.3 M, or ##STR2## and each oligosaccharide group contains 1 to 3 sugar groups; M is lithium, sodium, potassium, or ammonium;
n is 1 or 2;
X is a halogen, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms;
Y is carbonyl or sulfonyl;
Z is alkyl from 1 to 12 carbon atoms, ##STR3## and X is as defined above; or a pharmaceutically acceptable salt thereof.

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