Polyanhydrides with improved hydrolytic degradation properties

Details Polyanhydrides with improved hydrolytic degradation properties Polyanhydrides with improved hydrolytic degradation properties

1987-07-31

1989-08-15

Schoffer, Joseph L.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

528271, A61K 3174, C08G 6300

Patent

active

048573116

ABSTRACT:
Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in the range of 40.degree.-100.degree. C.
The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bioactive compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery. Furthermore, a desired degradation rate may be obtained by choosing the appropriate length of the aliphatic moiety.

REFERENCES:
patent: 2071250 (1937-02-01), Carother
K. W. Leong et al., 1985, J. of Biomed. Materials, vol. 19, 941-955.
Encyclopedia of Polymer Sci. & Tech., vol. 10 (1969), pp. 630-653.
Leong, et al., J. Biomed., Mater. Res. 20, 51 (1986).
Hill, J.A.C.S., 52, 4110, (1930).
Hill, J.A.C.S., 54, 1569, (1932).
Rosen, et al., Biomaterials 4, 131 (1983).
Leong, et al., Macromolecules 20(4), 705-712, (Apr. 1987).

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