Polyanhydride bioerodible controlled release implants for admini

Details Polyanhydride bioerodible controlled release implants for admini Polyanhydride bioerodible controlled release implants for admini

1989-03-31

1992-06-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 78, 424 81, 424426, A61K 3174

Patent

active

051223678

ABSTRACT:
A controlled release device for the administration of biologically active growth hormone proteins or peptide fragments, and method of preparation thereof, wherein biologically active growth hormone is stabilized and release rate modulated by incorporation of a stabilizing compound. The controlled release devices are prepared by mixing a stabilizer, such as sucrose, with a biologically active growth hormone, such as bovine somatotropic hormone, in solution, lyophilizing, then incorporating the dried powder into a surface erodible, biocompatible polymeric matrix, such as a poly(anhydride) or poly(orthoester) matrix.

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Mathiowitz et al., J. Controlled Release 5, 13-22 (1987).
Rosen et al., Biomaterials 4, 131-133 (1983).

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