Polyamines and anti-diarrheal and gastrointestinal anti-spasmodi

Details Polyamines and anti-diarrheal and gastrointestinal anti-spasmodi Polyamines and anti-diarrheal and gastrointestinal anti-spasmodi

1995-01-03

1995-10-31

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514655, 514674, 564367, 564512, A61K 31135, A61K 3113

Patent

active

054629705

ABSTRACT:
Anti-diarrheal, anti-secretory, nitric oxide agonist, nitric oxide synthase activating or gastrointestinal anti-spasmodic compounds of the formula: ##STR1## wherein: R.sub.1 and R.sub.6 may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms;

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patent: 5393757 (1995-02-01), Bergeron
Weinstock et al, "Synthesis of New Polyamine Derivatives for Cancer Chemotherapeutic Studies", Journal of Pharm. Sciences, vol. 70, No. 8, (1981).
Chantrapromma et al, "Chemistry of Naturally Occuring Polyamines", Tetrahedron Lett., vol. 22(1), 23-24, (1981).
Tansy et al, "Spermine and Spermidine as Inhibitors of Gastro Intestinal Motor Activity", Surg. Gynecol. Obstec., 154 (1), 74-80, (1982).
Aihara et al, "Polyamine Inhibition of Gastric Ulceration and Secretion in Rats", Biochem. Pharmacol., vol. 32(11), 1733-1736, (1983).
Ray et al, "Polyamines are Inhibitors of Gastric acid Secretion", Proc. Natl. Acad. Sci. USA, vol. 79 (5), 1448-1452, (1982).

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