Polyamine-linked acridine dimers

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D21912

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active

058861858

ABSTRACT:
A series of novel polyamine-linked acridine dimers and derivatives thereof are described. The polyamine-linked acridine dimers and derivatives are potential anti-cancer agents.

REFERENCES:
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Kraayenhof et al., On the interaction of 9-amino-substituted acridine probes with energy-conserving membranes, Dynamics of Energy-Transducin Membranes, Elsevier Scientific Publishing Co., New York, 1974.
LePecq et al., DNA polyintercalating drugs: DNA binding of diacridine derivatives, Proc. Nat. Acad. Sci, 72:8, pp. 2915-1919, 1975.
Markovits et al., Acridine dimers: influence of the intercalatin ring and of the linkin-chain nature on the equilibrium and kinetic DNA-binding parameters, Eur. J. Biochem, 180, pp. 359-366, 1989.
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