Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1995-06-01
1997-08-05
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564512, C07C21100
Patent
active
056544847
ABSTRACT:
The present invention relates to a method for the treatment of patients suffering from certain neoplastic disease states which comprises administering a therapeutically effective amount of a compound of the formula: ##STR1## wherein m is an integer 6 to 9, Z is a saturated (C.sub.2 -C.sub.6) alkylene moiety, each R group independently is hydrogen, methyl, ethyl, or n-propyl except that both R groups cannot be hydrogen when Z is a straight chain; or a pharmaceutically acceptable acid addition salt thereof. Said treatment can optionally comprise conjunctive therapy with a polyamine oxidase inhibitor. The invention also relates to certain novel polyamine derivatives.
Edwards Michael L.
Prakash Nellikunja J.
Stemerick David M.
Covington Raymond
Ivy C. Warren
Merrell Pharmaceuticals Inc.
Stemerick David M.
Wille Louis J.
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