Polyamine derivatives

Details Polyamine derivatives Polyamine derivatives

1994-03-15

1998-05-19

Lambkin, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514655, 564367, A61K 31135, C07C21143

Patent

active

057537143

ABSTRACT:
This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.

REFERENCES:
patent: 2267204 (1941-12-01), Kyrides
patent: 2279294 (1942-04-01), Hardman
patent: 2317757 (1943-04-01), Graf
patent: 2624759 (1953-01-01), Bersworth
patent: 2627491 (1953-02-01), Szabo et al.
patent: 2653977 (1953-09-01), Craig et al.
patent: 2770653 (1956-11-01), Haslick et al.
patent: 3013020 (1961-12-01), Fancher
patent: 3369905 (1968-02-01), Jones et al.
patent: 3689646 (1972-09-01), Sevag
patent: 3697659 (1972-10-01), Marco
patent: 3912816 (1975-10-01), Hofmann et al.
patent: 3933913 (1976-01-01), Colella et al.
patent: 4010200 (1977-03-01), Kalopissis et al.
patent: 4014937 (1977-03-01), Richardson
patent: 4048324 (1977-09-01), Kohn
patent: 4058624 (1977-11-01), Jacobus et al.
patent: 4092432 (1978-05-01), Bjorklund et al.
patent: 4172094 (1979-10-01), Dybas et al.
patent: 4182849 (1980-01-01), Ezzell
patent: 4258061 (1981-03-01), Gronin et al.
patent: 4311709 (1982-01-01), Dybas et al.
patent: 4321190 (1982-03-01), Costanzi et al.
patent: 4322530 (1982-03-01), Jachimowicz
patent: 4499072 (1985-02-01), Sunkara et al.
patent: 4505861 (1985-03-01), Bergeron, Jr.
patent: 4507321 (1985-03-01), Raisfeld
patent: 4559362 (1985-12-01), Umezawa et al.
patent: 4591605 (1986-05-01), Ray
patent: 4719313 (1988-01-01), Gerhart et al.
patent: 5013760 (1991-05-01), Farmer et al.
patent: 5091576 (1992-02-01), Bergeron
patent: 5109024 (1992-04-01), Prakash et al.
Bergeron, "Acc. Chem. Res.", vol. 19, pp. 105-113(1986) (I).
A. Lehninger, "Biochemistry" 2nd Ed., pp. 716-718, Worth Publishers, Inc., New York (1975).
Brown et al, "Fungicidal Activity and Chemical Constitution XXI. The Fungatoxicity of Aliphatic Polyamines", Pest. Sci. (1983), 4, 485-490.
Chem. Abstr. #116(23): 227654d of Farmaco, 46 (10), 1167-78, Minarini et al, "Further Investigation on Methotramine-Related Tetraamines" (1991).
Chem. Abstr. #113(11): 97320s of Arch. Pharm. (Weinheim, Ger.), 323(5), 287-94, Rehse et al, Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines (1990).
Chem. Abstr. #88(5): 32006g of Acta Med. Scand., Suppl., 606, 95-100, Clark B.J., "Dopamine Receptor Stimulants in Hypertension", (1976).
Chem. Abstr. #83(19): 163798u of Ger. Offen., 15 pp., Pless J. "Phenylethylamine Derivatives", (1975).
Edwards et al, "Polyamine Analogues with Antitumor Activity", J. Med. Chem., vol. 33, pp. 1369-1375, 1990.
Edwards, M.L., et al., J. Med. Chem., 34, 2414-2410 (1991).
Bitonti, A.J., et al, Biochem. J., 257, 769-774 (1989).
Work, T.S., J.Chem.Soc. 1940, 1315, 1940.
Goodson, J.A., et al., Brit.J.Pharmacol. 3, 49-61, 1948.
Roe, A.M., et al., J.Chem.Soc.(C) Org. 527-530, 1966.
Brown, D., et al., Pestic.Sci., 4, 485-490, 1973.
van Alphen, J., Rec. Trav. Chim. 59: 31-40, 1940.
van Alphen, J., Rec. Trav. Chim. 58: 544-9, 1939.
Israel, M., et al., J. Med. Chem. 7, 710-716, 1964.
Israel, M., et al., J. Med. Chem. vol. 14, No. 11, 1042-1047, 1971.
Weinstock, L.T., et al., J. Pharm. Sci. 70, 956-959, 1981.
Stevens, L., Biochem. J. 103, 811-815, 1967.
Clay, R.M., et al., Inorg. Chem. 24(21), 3330-6, 1985 as abstracted in Chemical Abstracts 103, No. 16, Oct. 85, p. 703, No. 133893K.
MArkovitsi, D. et al., Nouv. J. Chim. 5(3), 141-7, 1981 as abstracted in Chem Abstracts 94, 214950z.
Takahashi, M., et al., J. Biochem. 100(1), 123-31, 1986 as abstracted in Chem. Abstracts 105, 167691.
Weitl, F.L., et al., J. Org. Chem. 46, 5234-5237, 1981.
Melchiorre, C., et al., J. Med. Chemistry vol. 21, No. 11, 1126-1132, 1978.
Brasili, L., et al., Life Sciences vol. 38, pp. 1633-1640, 1986.
Goto, M. et al., Inorg. Chem. 9(6), 1488-96, 1970 abstracted in Chemical Abstracts 73 No. 4, Jul. 1970, p. 462, No. 20934t.
Melchiorre, C., et al., J. Med. Chem. 30, 201-204, 1987.
van Alphen, J., Rec. Trav. Chim. 58, 1105-8, 1939, as abstracted in Chemical Abstracts vol. 34, 2331, 1940.
Lehninger, A. L., Biochemistry, Second Edition, 716-718, 1975.
Baumann, R. J., et al., Antimicrobial Agents and Chemotherapy, pp. 722-727, May 1990.
Bitonti, Alan J. et al., Biochem. J. 257, 769-774, 1989.
Bitonti, A.J., Biochem. Pharm.Short Communication, 1989.
Assef, G., et al., Bulletin de la Societe Chimique de France, No. 3-4, II-165-176, 1979.

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