Polyamine analogs that activate antizyme frameshifting

Details Polyamine analogs that activate antizyme frameshifting Polyamine analogs that activate antizyme frameshifting

2005-07-05

2005-07-05

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S645000, C564S305000, C564S306000, C564S336000

Reexamination Certificate

active

06914079

ABSTRACT:
Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

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Stewart, K.D. et al, Surevy of the DNA Binding Properties of Natural and Synthetic Polyamino Compounds, Journal of Physical Organic Chemistry, vol. 5, 1992,: 461-466.

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