Polyamide resin and method for preparation of reagents for immun

Details Polyamide resin and method for preparation of reagents for immun Polyamide resin and method for preparation of reagents for immun

1989-06-19

1990-11-27

Schofer, Joseph L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

526204, 526206, 526288, 526306, 5263073, C08F 2054

Patent

active

049736388

ABSTRACT:
A polyamide resin for use in peptide and protein synthesis, and a method of preparing and using same. The polyamide resin is prepared by mixing a dimethylacrylamide monomer with an N-acrylyl-diaminoalkane functional monomer in an aqueous solution together with a cross-linker and emulsifying the aqueous solution in an organic solvent. An initiator and a promoter are added to polymerize the N-acrylyl-diaminoalkane functional monomer, dimethylacrylamide monomer, and cross-linker in the form of beads. The pH of the mixture is controlled during the polymeriztion. The beads are used as a solid phase for peptide and protein synthesis according to methods known in the art. The conjugate of the polyamide resin and the synthesized peptide or protein is used directly for immunoassays or immuniaztion without the need for separation of the peptide or protein from the resin and subsequent purification.

REFERENCES:
patent: 2893970 (1959-07-01), Caldwell et al.
Atherton, E. et al., "Polyamide Supports for Polypeptide Snythesis", 97 J. Am. Chem. Soc. 6584, (1975).
Stahl, G. L., et al., "Preparation and Characterization of Beaded Poly(N-acrylylpyrrolidine): Bidirectional Synthesis of Cys-, His-, Gln-, or Glu-Containing Polypeptides", 101 J. Am. Chem. Soc. 5383 (1979).

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