Polyalkylene glycol acid additives

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From organic oxygen-containing reactant

Reexamination Certificate

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C528S271000, C528S361000, C514S001000, C514S025000, C424S193100, C424S194100

Reexamination Certificate

active

10625033

ABSTRACT:
A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.

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patent: 5672662 (1997-09-01), Harris et al.
patent: 6495659 (2002-12-01), Bentley et al.
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patent: WO 01/26692 (2001-04-01), None
patent: WO 01/46291 (2001-06-01), None
Ekwuribe et al, Hydrophilic and lipophilic balanced microemulsion formulations of free form and/or conjugation-stbilized thereapeutic agents such as insulin, , 2001, Chem Abstract 134: 183490.
Brenner, et. al.,(1978) Am. J. Physiol., 234, F455.
Zalipsky, et. al., and Harris et. al in Poly(ethylene glycol) Chemistry: Biotechnical and Biomedical Applications; J.M. Harris ed., Plenum Press: NY (1992), Chap. 21 and 22.
Monfardini, C., et al, Bioconjugate Chemistry, American Chemical Society, Washington, US, XP000494804, vol. 6, No. 1, pp. 62-69 (1995).

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