Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Patent
1986-12-09
1989-04-18
Marantz, Sidney
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
436531, 436535, G01N 33547
Patent
active
048227471
ABSTRACT:
An immobilized hapten reagent for use in a specific binding assay for the determination of a hapten or binding analog thereof in a liquid test sample and methods for preparing and using the immobilized hapten reagent. The immobilized hapten reagent comprises a hapten moiety covalently linked substantially only to the external surface of a polyacrylamide gel particle. The immobilized hapten reagent is prepared by forming a reaction mixture comprising the hapten moiety and the carrier material in a nonswelling solvent wherein the gel particle is substantially impervious to the hapten moiety and wherein an analytically insignificant amount of the hapten moiety is nonspecifically bound to the gel particle. The immobilized hapten reagent is characterized by being substantially stable in aqueous solutions and exhibits an insignificant amount of leakage of the hapten moiety into a liquid test medium.
REFERENCES:
patent: 3793445 (1974-02-01), Updike
patent: 3966897 (1976-06-01), Renn
patent: 3970429 (1976-07-01), Updike
patent: 4446232 (1984-05-01), Liotta
patent: 4551426 (1985-11-01), Freytag
Johnson Richard D.
Runzheimer H. Volker
Sommer Ronald G.
Yip Kin F.
Collins Daniel W.
Marantz Sidney
Miles Inc.
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