Polyacrolein-type microspheres

Details Polyacrolein-type microspheres Polyacrolein-type microspheres

1985-09-04

1988-11-08

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

260513B, 424 943, 424497, 42721334, 42840224, 428407, 436501, 436532, 436547, 523223, 524547, 526315, 526909, A61K 958, B01J 1302, C08F 1634, C12N 1108

Patent

active

047833360

ABSTRACT:
Suspension polymerization of acrolein type compounds in the presence of appropriate surfactants results in the formation of microspheres in size ranging from 0.03 to 80 microns. Fluorescent and magnetic microspheres are obtained by carrying out the same polymerization in the presence of appropriate fluorochromic or ferrofluidic compounds, respectively. Hybrido-polyacrolein microspheres are obtained by grafting one type of such microspheres on another type. Immunomicrospheres were formed by binding covalently at physiological pH appropriate proteins to the microspheres. The immunomicrospheres can be used for various biological applications, such as specific markers for labeling cell surface receptors, for cell separation, for diagnostic purposes, etc.

REFERENCES:
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patent: 4413070 (1983-11-01), Rembaum
patent: 4552812 (1985-11-01), Margel et al.
patent: 8183217 (1965-05-01), Serniuk et al.
Margel et al.: "Polyacrolein Microspheres as a New Tool in Cell Biology", J. Cell Science, vol. 56, pp. 157-175 (1982).
Kronick et al.: "Magnetic Microspheres Prepared by Redox Polymerization" . . . , Science, vol. 200, Jun. 2, 1978, pp. 1074-1076.
Ryder, Jr. et al., "Polymerization of Acrolein by Redox Initiation", Journal of Polymer Science: Part A, vol. 3, pp. 3459-3469 (1965).
Pourfarzaneh et al.: "Composite Polyacrolein-Coated Cellulose Magnetizable Particles . . . " Clinica Chimica Acta 111: 61-63 (Mar. 1981).

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