Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-04-19
2011-04-19
Carlson, Karen Cochrane (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07928195
ABSTRACT:
Polynucleotides encoding chimeric proteins, and methods for their production and use are disclosed. The chimeric proteins comprise a flexible linker between two zinc finger DNA-binding domains, wherein the linker contains eight or more amino acids between the second conserved histidine residue of the carboxy-terminal zinc finger of the first domain and the first conserved cysteine residue of the amino-terminal zinc finger of the second domain.
REFERENCES:
patent: 4990607 (1991-02-01), Katagiri et al.
patent: 5096814 (1992-03-01), Aivasidis et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5243041 (1993-09-01), Fernandez-Pol
patent: 5302519 (1994-04-01), Blackwood et al.
patent: 5324638 (1994-06-01), Tao et al.
patent: 5324818 (1994-06-01), Nabel et al.
patent: 5324819 (1994-06-01), Oppermann et al.
patent: 5340739 (1994-08-01), Stevens et al.
patent: 5348864 (1994-09-01), Barbacid et al.
patent: 5350840 (1994-09-01), Call et al.
patent: 5356802 (1994-10-01), Chandrasegaran
patent: 5376530 (1994-12-01), De The et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5436150 (1995-07-01), Chandrasegaran
patent: 5487994 (1996-01-01), Chandrasegaran
patent: 5498530 (1996-03-01), Schatz et al.
patent: 5578483 (1996-11-01), Evans et al.
patent: 5597693 (1997-01-01), Evans et al.
patent: 5639592 (1997-06-01), Evans et al.
patent: 5674738 (1997-10-01), Abramson et al.
patent: 5702914 (1997-12-01), Evans et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 5792640 (1998-08-01), Chandrasegaran
patent: 5869618 (1999-02-01), Lippman et al.
patent: 5871902 (1999-02-01), Weininger et al.
patent: 5871907 (1999-02-01), Winter et al.
patent: 5916794 (1999-06-01), Chandrasegaran
patent: 5939538 (1999-08-01), Leavitt et al.
patent: 5972615 (1999-10-01), An et al.
patent: 6001885 (1999-12-01), Vega et al.
patent: 6007988 (1999-12-01), Choo et al.
patent: 6013453 (2000-01-01), Choo et al.
patent: 6110747 (2000-08-01), Blaschuk et al.
patent: 6140466 (2000-10-01), Barbas, III et al.
patent: 6479626 (2002-11-01), Kim et al.
patent: 6534261 (2003-03-01), Cox, III et al.
patent: 6903185 (2005-06-01), Kim et al.
patent: 7153949 (2006-12-01), Kim et al.
patent: 7595376 (2009-09-01), Kim et al.
patent: 2002/0173006 (2002-11-01), Kim et al.
patent: 0 875 567 (1998-11-01), None
patent: WO 95/19431 (1995-07-01), None
patent: WO 96/06110 (1996-02-01), None
patent: WO 96/06166 (1996-02-01), None
patent: WO 96/11267 (1996-04-01), None
patent: WO 96/20951 (1996-07-01), None
patent: WO 96/32475 (1996-10-01), None
patent: WO 97/27212 (1997-07-01), None
patent: WO 97/27213 (1997-07-01), None
patent: WO 98/53057 (1998-11-01), None
patent: WO 98/53058 (1998-11-01), None
patent: WO 98/53059 (1998-11-01), None
patent: WO 98/53060 (1998-11-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/36553 (1999-07-01), None
patent: WO 99/41371 (1999-08-01), None
patent: WO 99/42474 (1999-08-01), None
patent: WO 99/45132 (1999-09-01), None
patent: WO 99/47656 (1999-09-01), None
patent: WO 99/48909 (1999-09-01), None
patent: WO 00/23464 (2000-04-01), None
patent: WO 00/27878 (2000-05-01), None
patent: WO 01/53480 (2001-07-01), None
Agarwal et al., “Stimulation of Transcript Elongation Requires Both the Zinc Finger and RNA Polymerase II Binding Domains of Human TFIIS,”Biochemistry30(31):7842-7851 (1991.
Antao et al., “A Thermodynamic Study of Unusually Stable RNA and DNA Hairpins,”Nuc. Acids. Res. 19(21):5901:5905 (1991).
Barbas, C.F., “Recent Advances in Phage Display,”Curr. Opin. Biotech. 4:526-530 (1993).
Barbas et al., “Assembly of Combinatoria Antibody Libraries on Phage Surfaces: The Gene III Site,”PNAS88:7978-7982 (1991).
Barbas et al., “Semisynthetic Combinatorial Antibody Libraries: A Chemical Solution to the Diversity Problem,”PNAS89:4457-4461 (1992).
Beerli et al., “Toward Controlling Gene Expression at Will: Specific Regulation of the erbB-2/HER-2 Promoter by Using Polydactyl Zinc Finger Proteins Constructed From Modular Building Blocks,”Proc. Natl. Acad. Sci. U.S.A. 95:14628-14633 (1998).
Bellefroid et al., “Clustered Organization of Homologous KRAB Zinc-Finger Genes with Enhanced Expression in Human T Lymphoid Cells,”EMBO J. 12(4):1363-1374 (1993).
Berg, J.M., “DNA Binding Specificity of Steriod Receptors,”Cell57:1065-1068 (1989).
Berg, J.M., “Sp1 and the Subfamily of Zinc-Finger Proteins with Guanine-Rich Binding Sites,”PNAS89:11109-11110 (1992).
Berg, J.M., “The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc,”Science271:1081-1085 (1996).
Berg, J.M., “Letting Your Fingers do the Walking,”Nature Biotechnology15:323 (1997).
Bergqvist et al., “Loss of DNA-binding and new Transcriptional Trans-Activation Function in Polyomavirus Large T-Antigen with Mutation of Zinc Finger Motif,”Nuc. Acids Res. 18(9):2715-2720 (1990).
Blaese et al., “Vectors in Cancer Therapy: How Will They Deliver?,”Cancer Gene Therapy2(4):291-297 (1995).
Caponigro et al, “Transdominant Genetic Analysis of a Growth Control Pathway,”PNAS95:7508-7513 (1998).
Celenza et al., “A Yeast Gene That is Essential for Release from Glucose Repression Encodes a Protein Kinase,”Science233:1175-1180 (1996).
Cheng et al., “Idenfication of Potential Target Genes for Adrip through Characterization of Essential Nucleotides in UASI.”Mol. Cellular Biol. 14(6):3842-3852 (1994).
Cheng et al., “A Single Amino Acid Substitution in Zinc Finger 2 of Adrlp Changes its Binding Specificity at Two Positions in UAS1,”.J. Mol. Biol. 251:1-8 (1995).
Choo et al., A Role in DNA-Binding for the Linker Sequences of the First Three Zinc Fingers of TFIIIANuc. Acids Res. 21(15):3341-3346 (1995).
Choo et al., “Promoter-Specific Activation of Gene Expression Directed By Bacteriophage-Selected Zinc Fingers,”J. Mol. Biol. 273:525-532 (1997).
Choo et al., “Designing DNA-Binding Proteins on the Surface of Filamentous Phage,”Curr. Opin. Biotechnology6:431-436 (1995).
Choo, Y., “Recognition of DNA Methylation by Zinc Fingers,”Nature Struct Biol. 5(4):264-265 (1998).
Choo et al., “All Wrapped Up,”Nature Struct Biol5(4):253-255 (1998).
Choo, Y., “End Effects in DNA Recognition Code,”Nuc. Acids. Res. 26(2):554-557 (1998).
Choo et al., Physical Basis of Protein-DNA Recognition Code,Curr. Opin. Struct. Biol. 7(1):117-125 (1997).
Choo et al., “Toward a Code for the Interactions of Zinc Fingers With DNA: Selection of Randomized Fingers Displayed on Phage,”Proc. Natl. Acad. Sci. U.S.A. 91:11163-11167 (1994).
Choo et al., “Selection of DNA Binding Sites for Zinc Fingers Using Randomized DNAs Reveals Coded Interactions,”Proc. Natl. Acad. Sci. U.S.A. 91:11168-11172 (1994).
Choo et al., “In vivo Repression by a Site-Specific DNA-Binding Protein Designed against an Oncogenic Sequence,”Nature372:642-645 (1994).
Clarke et al., “Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways,” Science 282:2018-2022 (1998).
Clemens et al., “Relative Contributions of the Zinc Fingers of Transcription Factor IIIA to the Energetics of DNA Binding,”J. Molecular Biology244(1):23-25 (1994).
Corbi et al., “Synthesis of a New Zinc Finger Peptide: Comparison of Its “Code” Deduced and “CASTing” Derived Binding Sites,”FEBS Letters417:71-74 (1997).
Crozatier et al., “Single Amino Acid Exchanges in Separate Domains of the Drosophila Serendipity Zinc Finger Protein Cause Embryonic and Sex Biased Lethality,”Genetics131:905-916 (1992).
Debs et al., “Regulation of Gene Expression in Vivo by Liposome-Mediated Delivery of a Purified Transcription Factor,”J. Biological Chemistry265(18):10189-10192 (1990).
Desjarlais et al., “Redesigning t
Kim Jin-Soo
Pabo Carl O.
Carlson Karen Cochrane
Massachusetts Institute of Technology
Pasternak Dahna S.
Robins & Pasternak LLP
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