Poly(organophosphazene) hydrogels for drug delivery,...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

Reexamination Certificate

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C424S085200, C424S085500, C424S085600, C424S085700, C424S093700, C424S130100, C424S141100, C424S184100, C424S225100, C514S002600, C514S003100, C514S008100, C514S012200, C514S034000, C528S339000

Reexamination Certificate

active

08075916

ABSTRACT:
A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.

REFERENCES:
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patent: 6319984 (2001-11-01), Song et al.
patent: 2009/0022683 (2009-01-01), Song et al.
patent: 10 2000 0002785 (2000-01-01), None
patent: 10 2001 0047025 (2001-06-01), None
patent: 2005-0012533 (2005-02-01), None
patent: 2007-0076386 (2007-07-01), None
patent: 10-0746962 (2007-08-01), None
patent: 01-36516 (2001-05-01), None
patent: 2005-010079 (2005-02-01), None
patent: 2006-033523 (2006-03-01), None
patent: 2007-014549 (2007-02-01), None
patent: 2007-083875 (2007-07-01), None
Search results (STIC/STN).
Human translation for KR 10-2007-0076386 ref. of record (pdf).
U.S. Patent Documents—None.
Non-Patent Documents—None.
Byeongmoon Jeong, et al. “Biodegradable block copolymers as injectable drug-delivery systems” Nature, 388, pp. 860-862 (1997).
Lev E. Bromberg, et al. “Temperature-responsive gels and thermogelling polymer matrics for protein and peptide delivery” Adv Drug Deliv Rev, 31, pp. 197-221 (1998).
Yoshiki Katayama et al, A polymer Micelle Responding to the Protein Kinase A Signal Marcromolecules, 34, 8569, pp. 8569-8573 (2001).
Soo-Chang Song, et al “A New Class of Biodegradable Thermosensitive Polymers. I. Synthesis and Characterization of Poly (organophosphazenes) with Methoxy-Poly(ethylene glycol) and Amino Acid Esters as Side Groups” Marcromolecules, 32, pp. 2188-2193 (1999).
Sang Beom Lee, et al “A new class of biodegradable thermosensitive polymers. 2. Hydrolytic properties and salt effect on the lower critical solution temperature of poly(organophosphazenes) with methoxypoly(ethylene glycol) and amino acid esters as side groups” Marcromolecules, 32, pp. 7820-7827 (1999).
Bae Hoon Lee, et al. “A Thermosensitive Poly (organophosphazene) Gel” , Marcromolecules, 35, pp. 3876-3879 (2002).
Kim. J. Y. Synthesis and characterization of thermosensitive poly(organophosphazenes) Gels with Bioactive Molecules' in Degree of Master Thesis, Chonbuk National University, 2005, abstract, pp. 11, 19-47, and 77, and Scheme 3-1 and 3-2.
Kang, G. D. et al. The Thermosensitive poly (organophosphazenes) hydrogels for a controlled drug delivery. Eur. J. of Pharm. Biopharm. Mar. 2006, vol. 63, pp. 340-346, ISSN 0939-6411.
Yuk, S.H. et al. Polymeric Protein Delivery Systems. Progs. Sci. May 2007, vol. 32, pp. 669-697, ISSN 0079-6700.
Mieke Heyde et al: “Synthesis and Characterization of Novel Poly [(organo) phosphazenes] with Cell-Adhesive Side Groups”, Biomacromolecules, Biomacromolecules 2007, 8, 1436-1445.
Kang G D et al: “Controlled release of doxorubicin from thermosensitive poly (organophosphazene) hydrogels”, International Journal of Pharmaceurics, 319 (2006) pp. 29-36.

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