Poly (organophosphazene) hydrogels

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From phenol – phenol ether – or inorganic phenolate

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528167, 528169, 528228, 528229, 528367, 528368, 528369, 528399, C08G 7902

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active

058980628

ABSTRACT:
Poly (organophosphazene) polymers bearing various ratios of a carboxylic acid containing sidegroup and an alkylamino, alkoxy, or alkoxy ether sidegroup are disclosed. These water-soluble macromolecules are cross-linked and allowed to absorb water to form hydrogels. Because of their anionic character and high water content, the polymeric hydrogels are useful for a wide variety of biomedical applications including controlled drug delivery (e.g. pH sensitive drug delivery), biocompatible coatings, and pH sensitive membranes.

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Cohen, et al., J. Am. Chem. Soc., 112, p. 7832-7833 (1990).
Allcock, et al., Macromolecules, 25, pp. 5573-5577 (1992).

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