Poly-kringle plasminogen activator

Details Poly-kringle plasminogen activator Poly-kringle plasminogen activator

1986-07-11

1990-04-10

Huleatt, Jayme A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435215, 435226, C12N 948, C12N 972, C12N 964

Patent

active

049160710

ABSTRACT:
Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.

REFERENCES:
patent: 4752581 (1988-06-01), Robinson et al.
patent: 4766075 (1988-08-01), Goeddel et al.
Nelles, L. et al., J. Biol. Chem, vol. 262, pp. 10855-10862, 1987.
Gheysen, D. et al., J. Biol. Chem, vol. 262, pp. 11779-11784, 1987.
Pierardi, L. et al., J. Biol. Chem, vol. 262, pp. 11771-11778, 1987.

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