Poly(ethylene glycol) aldehyde hydrates and related polymers and

Details Poly(ethylene glycol) aldehyde hydrates and related polymers and Poly(ethylene glycol) aldehyde hydrates and related polymers and

1998-05-20

1999-11-23

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 56, 525107, 525154, C07C10352, C08L 8900

Patent

active

059902370

ABSTRACT:
The present invention provides a method of coupling PEG or related polymers to a substance by reductive amination. An activated PEG having an aldehyde hydrate moiety is prepared and is conveniently used as an intermediate for coupling PEG to a variety of biomolecules by reductive amination. The method of making PEG-conjugated biomolecules in accordance with the present invention avoids the condensation and oxidation reactions that are inherent in the coupling methods employed heretofore in the prior art using PEG aldehyde. As a result, high purity of PEG-conjugates can be achieved.

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patent: 5252714 (1993-10-01), Harris et al.
Functionalized Poly(ethylene glycol) for Preparation of Biologically Conjugates, Bioconjugate Chem. 1995, 6: 150-165, Samuel Zalipsky.
Modification of CD4 Immunoadhesin with Monomethoxpoly(ethylene glycol) Aldehyde via Reductive Alkylation, Bioconjugate Chem. 1994, 5: 133-140, Steven M. Chamow, et al.

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