Poly (ADP-ribose) polymerase inhibitors to treat diseases associ

Details Poly (ADP-ribose) polymerase inhibitors to treat diseases associ Poly (ADP-ribose) polymerase inhibitors to treat diseases associ

1996-08-27

1999-02-23

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514305, 514306, 514307, 514456, 514457, 514613, 514617, A61K 3147, A61K 3144, A61K 3135, A61K 3116

Patent

active

058744444

ABSTRACT:
Inhibition of the enzyme poly (ADP-ribose) polymerase can delay the onset of senescence and inhibitors of the enzyme can be used to treat diseases caused or exacerbated by cellular senescence.

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Lea, M.; Barra, R.; Randolph, V.; Kuhr, W.; "Effects of Nicotinamide and Structural Analogs on DNA Synthesis and Cellular Replication of Rat Hepatoma Cells"; Cancer Biochem Biophys.; 1984; vol. 7; pp. 195-202.
Banasik, M.; Komura, H.; Shimoyama, M.; Ueda, K.; "Specific Inhibitors of Poly (ADP-Ribose) Synthetase and Mono (ADP-Ribosyl) transferase"; The Journal of Biological Chemistry; vol. 267, No. 3; 25 Jan. pp. 1569-1575 (1992).
Rattan and Clark, 15 Jun. 94, "Kinetin delays the onset of ageing characteristics in human fibroblasts", Biochem. Biophys. Res. Comm. 201(2):665-672.

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