Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutic

Details Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutic Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutic

1993-08-06

1995-12-05

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514365, 514370, 514374, 514377, 514397, 514343, 548194, 548233, 548236, 5483147, 548518, 546281, A61K 3140, C07D20730

Patent

active

054729769

ABSTRACT:
This invention relates to polyaminopyrrolecarboxyamide derivatives of general formula (I) and their pharmaceutically acceptable salts, in which A represents a chemical bond or an aromatic or heteroaromatic radical, and:
if A is a chemical bond, R is hydrogen, alkyl, dialkylaminoalkyl, alkenyl, cycloalkyl, arylalkyl, arylalkenyl, haloalkyl, or an aromatic or heteroaromatic radical;
whereas if A is an aromatic or heteroaromatic radical, R is nitro, amino or formylamino;
n is 0 or a whole number between 1 and 4;
Z is an alkylene or aromatic radical. ##STR1##

REFERENCES:
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patent: 4766142 (1988-08-01), Arcamone et al.
patent: 4912199 (1990-03-01), Lown et al.
patent: 5049579 (1991-09-01), Lazzari et al.
CA 67(7):32586v Amidines, Rhone-Poulenc, p. 3079, 1967.
CA 67(7):32589y 1-Alkyl-2-N-(amidinoalkyl)carbamoyl-4-acylamino-pyrroles. p. 3079, 1967.
CA 97(17):13184x Antiparasitic . . . A derivatives. Bialer et al., pp. 25-26, 1982.
J. Med. Chem. vol. 29, No. 7 (1987), pp. 1210-1214, Structure-Activity Relationship of Novel . . . Distamycin.

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