Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Patent
1989-01-31
1990-05-01
Tokar, Michael J.
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
324309, G01R 3320
Patent
active
049222031
ABSTRACT:
A nuclear magnetic resonance (NMR) image is obtained with spatial information modulated by chemical information. The modulation is obtained through polarization transfer from a first element representing the desired chemical, or functional, information, which is covalently bonded and spin-spin coupled with a second element effective to provide the imaging data. First and second rf pulses are provided at first and second frequencies for exciting the imaging and functional elements, with imaging gradients applied therebetween to spatially separate the nuclei response for imaging. The second rf pulse is applied at a time after the first pulse which is the inverse of the spin coupling constant to select the transfer element nuclei which are spin coupled to the functional element nuclei for imaging. In a particular application, compounds such as glucose, lactate, or lactose, can be labeled with .sup.13 C and metabolic processes involving the compounds can be imaged with the sensitivity of .sup.1 H and the selectivity of .sup.13 C.
REFERENCES:
patent: 3781650 (1973-12-01), Keller
patent: 4345207 (1982-08-01), Bertrand et al.
patent: 4443761 (1984-04-01), Levitt
patent: 4521732 (1985-06-01), Pegg et al.
patent: 4682107 (1987-07-01), Bendall et al.
patent: 4701708 (1987-10-01), Hardy et al.
Laurel O. Sillerud et al., "High-Resolution Proton NMR Studies of Intracellular Metabolites in Yeast Using .sup.13 C Decoupling," 45, J. Magn. Reson., 142-150, (1981).
Ray L. Nunnally et al., "Assessment of Pharmacological Treatment of Myocardial Infarction by Phosphorus-31 NMR with Surface Coils," 211, Science, 177-180, (1981).
Paul A. Bottomley, "NMR Imaging Techniques and Applications: A Review," 53, Rev. Sci. Instrum., No. 9, 1319-1337, (1982).
A. J. Shaka et al., "An Improved Sequence for Broadband Decoupling: WALTZ-16," 52, J. Magn. Reson., 335-338, (1983).
Lynn W. Jelinski, "Modern NMR Spectroscopy," Chem. Eng. News, 26-47, (Nov. 5, 1984).
R. E. Sepponen et al., "A Method for Chemical Shift Imaging: Demonstration of Bone Marrow Involvement with Proton Chemical Shift Imaging," 8, J. Comput. Assist. Tomogr., No. 4, 585-586, (1984).
J. K. T. Lee et al., "Fatty Infiltration of the Liver: Demonstration by Proton Spectroscopic Imaging," 153, Rad., No. 1, 195-201, (1984).
W. T. Dixon, "Simple Proton Spectroscopic Imaging," 153, Rad., No. 1, 189-194, (1984).
P. A. Bottomley et al., "In Vivo Nuclear Magnetic Resonance Chemical Shift Imaging by Selective Irradiation," 81, Proc. Natl. Acad. Sci., 6856-6860, (Nov. 1984).
Laurance D. Hall et al., "Three-Dimensional Fourier Transform NMR Imaging, High Resolution Chemical-Shift Resolved Planar Imaging," 56, J. Magn. Reson., 314-317, (1984).
Yishay Manassen et al., "A Constant Gradient Experiment for Chemical-Shift Imaging," 61, J. Magn. Reson., 363-370, (1985).
Joel F. Martin et al., "Chemical-Shift Encoding in NMR Images," 61, J. Magn. Reson., 153-157, (1985).
W. P. Que et al., "Localized .sup.13 C NMR Spectra with Enhanced Sensitivity Obtained by Volume-Selective Excitation," 61, J. Magn. Reson., 392-395, (1985).
H. P. Heatherington et al., ".sup.1 H Homonuclear Editing of Rat Brain Using Semiselective Pulses," 82, Proc. Natl., Acad. Sci. U.S.A., 3115-3118, (May 1985).
R. J. Ordidge et al., "Image-Selected in Vivo Spectroscopy (ISIS), A New Technique for Spatially Selective NMR Spectroscopy," 66, J. Magn. Reson., 283-294, (1986).
T. Jue, "Winnowing the {.sup.13 C}-.sup.1 H Resonances in the in Vivo NMR Spectrum," 71, J. Magn. Reson., 532-538, (1987).
Laurel O. Sillerud et al., "{.sup.13 c}-Polarization Transfer Proton NMR Imaging of a Sodium [.sup.13 C] Formate Phantom at 4.7 Tesla," 76, J. Magn. Reson., 380-385, (Feb. 1988).
Sillerud Laurel O.
van Hulsteyn David B.
Gaetjens Paul D.
Moser William R.
The United States of America as represented by the United States
Tokar Michael J.
Wilson Ray G.
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