Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1996-12-10
1998-07-07
Naff, David M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424439, 424440, 424441, 424464, 514888, A61K 3578, A61K 4700, A61K 968, A61K 920
Patent
active
057764620
ABSTRACT:
The attachment of H. influenzae to human cells such as oropharyngeal cells, is inhibited by aqueous extracts of the plants known as Pogostemon cablin and Agastache rugosa. The composition obtained from the aqueous extraction of the plants Pogostemon cablin, Agastache rugosa or mixtures thereof is also effective in preventing or treating Otitis media and sore throat. The plant extract may be contained in a liquid enteral product such as an infant formula or may be incorporated into lozenges, candies, chewing gums and the like. The plant extract may also be administered as a throat spray or nasally using drops or a spray. A process for the production of a medicinal product is also disclosed.
REFERENCES:
patent: 4784853 (1988-11-01), Inoi et al.
patent: 5137922 (1992-08-01), Shimamura et al.
Hong-Yen Hsu, Yuh-Pan Chen, Shun-Gi Hsu, Jau-Shin Hsu, Cheng-Jyh Chen, & Hsien-Chang Chang, Concise Pharmacognosy, New Medicine Publishing Co., Taipei, Taiwan, R.O.C., pp. 303-304 (1985).
Hsien-Chang Chang, Medicinal Herbs II, Holiday Publishing Co., Taipei, Taiwan, R.O.C., 67 (1991).
Woei-Song Kan, Pharmaceutical Botany, National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C., 485 (1971).
Woei-Song Kan, Pharmaceutical Botany, National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C., 475 (1971).
Morse et al., Haemophilus, Microbiology, Fourth Edition, published by J.B. Lipincott Company, pp. 615-618 (1990).
Stephens et al., Pathogenic Events During Infection of the Human Nasopharynx with Neisseria meningitis and Haemophilus influenza, Reviews of Infectious Diseases, 13:22-23 (1991).
Harada et al., Adherence of Haemophilus influenzae to nasal, nasopharyngeal and bucal epithelial cells from patients with otitis media, European Archives of Oto-rhino-laryngology, 247:122-124 (1990).
Stenfors et al., Abundant Attachment of Bacteria to Nasopharyngeal Epithelium in Otitis-Prone Children, The Journal of Infectious Diseases, 165:1148-1150 (1992).
Bakaletz et al., Frequency of Fimbriation on Nontypable Haemophilus influenzae and its Ability to Adhere to Chinchilla and Human Respiratory Epthelium, Infection and Immunity, 56: 331-335 (1988).
Weiser, Relationship between Colony Morphology and the Life Cycle of Haemophilus influenzae: the Contribution of Lipopolysaccharide Phase Variation to Pathogenesis, The Journal of Infectious Diseases, 168, 672-680 (1993).
Weiser, et al., Phase Variation in Pneumococcal Opacity: Relationship between Colonial Morphology and Nasopharyngeal Colonization, Infection and Immunity, 62, 2582-2589 (1994).
Nagai et al., Antiviral Research, 19:207-217, 1992.
Evans, Trease and Evans' Pharmacognosy, 13th Ed., Bailliere Tindall, London, GB, pp. 216-217, 1989.
Remington's Pharmaceutical Sciences, 18th Ed., Mack Publishing Co., Easton, PA, pp. 1519-1544, 1990.
The Merck manual of Diagnosis and Therapy, vol. 1, General Medicine, 15th Ed., Merck & Co., Inc., Rahway, NJ, pp. 131 and 132, 1987.
Ruoff, The Prokaryotes, 2nd Ed., vol. II, Springer-Verlag, New York, Inc., pp. 1450-1464, 1992.
Tortora et al., Microbiology, An Introduction, 5th Ed., The Benjamin/Cummings Publishing Co., Inc., pp. 390-393, 1995.
Ichikawa et al. Chem. Pharm. Bull. 37:345-348, 1989.
Hwang Shie-Ming
Tsai Hsiu-Hsien
Kerr Janet M.
Naff David M.
Nickey Donald O.
Sage R&D, a partnership
LandOfFree
Pogostemon cablin extract for inhibiting H. influenzae adhesion does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pogostemon cablin extract for inhibiting H. influenzae adhesion , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pogostemon cablin extract for inhibiting H. influenzae adhesion will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1202599