Pneumocystis carinii dihydrofolate reductase gene and methods fo

Details Pneumocystis carinii dihydrofolate reductase gene and methods fo Pneumocystis carinii dihydrofolate reductase gene and methods fo

1989-11-15

1992-11-17

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 435 91, 4351723, C07H 1512, C12P 2106, C12P 1936

Patent

active

051644908

ABSTRACT:
Genetic material encoding dihydrofolate reductase (DHFR) of Pneumocystis carinii has been isolated and characterized. This genetic material allows the production of peptides for use in the design of inhibitors specific for P. carinii DHFR (as opposed to DHFR in the host infected with P. carinii) or can itself be directly used in hybridization assays.

REFERENCES:
Edman, et al., P.N.A.S. 86:8625-8629, 1989.
Trimble, et al., Science 239:1145-1147, 1988.
Nunberg, et al., Cell 19:355-364, 1980.

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