Pneumococcal polysaccharide-recombinant pneumolysin conjugate va

Details Pneumococcal polysaccharide-recombinant pneumolysin conjugate va Pneumococcal polysaccharide-recombinant pneumolysin conjugate va

1994-08-24

1996-10-15

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 4241931, 42419711, 536105, 536126, A61K 3909, A61K 3900, A61K 3938, A61K 39385

Patent

active

055652042

ABSTRACT:
Immunogenic polysaccharide-protein conjugates are generated which have an oxidized polysaccharide derived from the capsular polysaccharide of Streptococcal pneumniae and the pneumolysin protein of S. pneumoniae which is expressed recombinantly. The pneumolysin is not toxoided prior to conjugation with said oxidized polysaccharide. The immunogenic conjugates are used as vaccines to elicit antibody responses to the capsular polysaccharide of S. pneumoniae and to recombinant pneumolysin, and to immunize against S. pneumoniae-caused disease.

REFERENCES:
patent: 4242501 (1980-12-01), Cano et al.
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4673574 (1987-06-01), Anderson
patent: 4686102 (1987-08-01), Ritchey et al.
patent: 4761283 (1988-08-01), Anderson
patent: 4830852 (1989-05-01), Marburg et al.
patent: 4902506 (1990-02-01), Anderson et al.
patent: 5192540 (1993-03-01), Kuo et al.
patent: 5306492 (1994-04-01), Porro
patent: 5360897 (1994-11-01), Anderson et al.
patent: 5371197 (1994-12-01), Marburg et al.
patent: 5445817 (1995-08-01), Schneerson et al.
Phillips, J. R., et al., Carbohydrate Res., 121, 243-255 (1983).
Paton, J. C., et al., Infection & Immunity, 59, 2297-2304 (1991).
Boulnois, G. J., J. Gen. Microbiol., 138, 249-259 (1992).
Walker et al., 1987, Molecular cloning, characterization, and complete nucleotide sequence of the gene pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae, Infection and Immunity, 55(5):1184-1189.
Paton et al., 1983, Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae, Infection and Immunity, 40(2):548-552.
Paton et al., 1986, Cloning and expression of Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin, Infection and Immunity, 54(1):50-55.
Rubins et al., 1992, Toxicity of Pneumolysin . . . Inf & Imm. 60(5):1740-46.
Paton, J. C., et al., Ann. Rev. Microbiol., 47, 89-115 (1993).
Lee, C.-J., et al., Vaccine, 12, 875-878 (1994).
Lee et al. 1994. Protection of infant mice from challenge with Streptococcus . . . Vaccine 12(10):875-878.
Lee et al. 1994. Pneumococcal infection and immunization in children. Critical Reviews in Microbiol. 20(1):1-12.

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